3-甲氧基-6-甲基-2-吡啶胺合成路线 （共 3 条）
反应条件
hydrogen; palladium on activated carbon in ethanol
2 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1591446 A1, 2005 ;
Location in patent: Page/Page column 27 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: EP2168960 A1, 2010 ;
Location in patent: Page/Page column 70 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Ochiai, Koji; Takita, Satoshi; Eiraku, Tomohiko; Kojima, Akihiko; Iwase, Kazuhiko; Kishi, Tetsuya; Fukuchi, Kazunori; Yasue, Tokutaro; Adams, David R.; Allcock, Robert W.; Jiang, Zhong; Kohno, Yasushi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 5 p. 1644 - 1658
