hydrogen iodide in tetrahydrofuran T=45°C; 1 h;

<b>Multi-step reaction with 5 steps<br /> </b>1: Et₃N / CH₂Cl₂ / 2 h / 20 &deg;C<br />2: Et₃N / CH₂Cl₂ / 20 &deg;C<br />3: 18.9 g / MeOH / CH₂Cl₂ / 0.25 h / 20 &deg;C<br />4: 99 percent / aq. LiOH / tetrahydrofuran / 0.25 h / 40 &deg;C<br />5: 34 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-methylmorpholine; 1-hydroxybenzotriazole / tetrahydrofuran / 1 h / 20 &deg;C<br /> <br /> &nbsp;