1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran T=22°C; 2 h; 2: 2-isopropoxybiphenyl-3-carbaldehyde in tetrahydrofuran T=-78 - 22°C; Wittig olefination;

1.1: 82 percent / K2CO3 / dimethylformamide / 12 h / Heating 2.1: potassium tert-butoxide / tetrahydrofuran / 2 h / 22 °C 2.2: 100 percent / tetrahydrofuran / -78 - 22 °C View Scheme

1.1: EtMgBr / tetrahydrofuran; diethyl ether / 0.17 h 1.2: 75 percent / triethylamine / benzene / 12 h / Heating 2.1: 82 percent / K2CO3 / dimethylformamide / 12 h / Heating 3.1: potassium tert-butoxide / tetrahydrofuran / 2 h / 22 °C 3.2: 100 percent / tetrahydrofuran / -78 - 22 °C View Scheme

1: 100 percent / K2CO3 / 12 h / 50 °C 2: LiAlH4 / tetrahydrofuran / Heating 3: MnO2 / diethyl ether / 12 h / 20 °C 4: tBuOK / diethyl ether / 0.17 h / 0 °C View Scheme

1: 40 percent / 24 h / 190 °C / 15200 Torr 2: 100 percent / K2CO3 / 12 h / 50 °C 3: LiAlH4 / tetrahydrofuran / Heating 4: MnO2 / diethyl ether / 12 h / 20 °C 5: tBuOK / diethyl ether / 0.17 h / 0 °C View Scheme

1: MnO2 / diethyl ether / 12 h / 20 °C 2: tBuOK / diethyl ether / 0.17 h / 0 °C View Scheme

1: LiAlH4 / tetrahydrofuran / Heating 2: MnO2 / diethyl ether / 12 h / 20 °C 3: tBuOK / diethyl ether / 0.17 h / 0 °C View Scheme