7-甲氧基苯并呋喃-2-甲酸合成路线 （共 16 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide 3 h; Heating;
参考文献
Varvaresou; Iakovou; Filippatos; Souli; Calogeropoulou; Ioannidou; Kourounakis; Pannecouque; Witvrouw; Padalko; Neyts; De Clercq; Tsotinis
Arzneimittel-Forschung/Drug Research, 2001 , vol. 51, # 2 p. 156 - 162
反应条件
hydrogenchloride; potassium hydroxide; potassium carbonate in ethanol; water; butanone
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6235771 B1, 2001 ;
反应条件
potassium hydroxide in ethanol 0.75 h; Heating;
参考文献
Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576
反应条件
1: K2CO3 / butan-2-one / 4 h / Heating 2: KOH / ethanol / 0.75 h / Heating View Scheme
参考文献
Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576
反应条件
sodium acetate T=160 - 180°C;
参考文献
v. Stockalper
Jahrb. philos. Fakultaet II Univ. Bern 4 <1924>, 28
反应条件
ethanol; sodium ethanolate anschliessend Erwaermen mit wss. Kalilauge;
参考文献
Reichstein et al.
Helvetica Chimica Acta, 1935 , vol. 18, p. 816,826
反应条件
1: 64 percent / Cu; quinoline / 2 h / Heating 2: 52 percent / BBr3 / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Reichstein et al.
Helvetica Chimica Acta, 1935 , vol. 18, p. 816,826
反应条件
copper in 1-methyl-pyrrolidin-2-one T=250°C; 0.833333 h;
参考文献
Zhang, Yun; Jamison, Timothy F.; Patel, Sejal; Mainolfi, Nello
Organic Letters, 2011 , vol. 13, # 2 p. 280 - 283
反应条件
lithium diisopropyl amide; methyl iodide
T=-90°C;
参考文献
Buttery, Cheryl D.; Knight, David W.; Nott, Andrew P.
Tetrahedron Letters, 1982 , vol. 23, # 40 p. 4127 - 4130
反应条件
lithium diisopropyl amide in tetrahydrofuran
1.) < -90 deg C, 0.25 h, 2.) warmed to room temperature; Yields of byproduct given;
参考文献
Buttery, Cheryl D.; Knight, David W.; Nott, Andrew P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2839 - 2843
