乙基5-甲基-3-(4-吡啶基)-1,2-恶唑-4-羧酸酯合成路线 （共 5 条）
反应条件
1: 4-Pyridinecarboxaldehyde oxime With pyridine; N-chloro-succinimide in chloroform
T=20°C; 0.5 h;
2: (Z)-3-pyrrolidin-1-yl-but-2-enoic acid ethyl ester With triethylamine in chloroform
T=50°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1408042 A1, 2004 ;
Location in patent: Page 30 ;
EP 1408042 A1
反应条件
1: pyridine-4-carboxaldoxime With pyridine; N-chloro-succinimide in chloroform
T=20°C; 0.75 h;
2: (E)-3-pyrrolidinobut-2-enoic acid ethyl ester With triethylamine in chloroform
T=20 - 50°C; 31.5 h;
参考文献
Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Lucas, Matthew C.; Thomas, Andrew
Patent: US2009/143371 A1, 2009 ;
Location in patent: Page/Page column 40 ;
US 20090143371 A1
反应条件
pyridine; N-chloro-succinimide; triethylamine in n-heptane; chloroform
参考文献
Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Thomas, Andrew
Patent: US2009/143385 A1, 2009 ;
反应条件
1: pyridine-4-carboxaldoxime With pyridine; N-chloro-succinimide in chloroform
T=50°C;
2: ethyl 3-(pyrrolidin-1-yl)but-2-enoate With triethylamine in chloroform
参考文献
Nakamura, Masayuki; Kurihara, Hideki; Suzuki, Gentaroh; Mitsuya, Morihiro; Ohkubo, Mitsuru; Ohta, Hisashi
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 726 - 729
反应条件
water; sodium hydroxide in methanol
参考文献
Nakamura, Masayuki; Kurihara, Hideki; Suzuki, Gentaroh; Mitsuya, Morihiro; Ohkubo, Mitsuru; Ohta, Hisashi
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 726 - 729
