5-甲氧基吲哚-2-甲酸乙酯合成路线 （共 27 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 15 h;
参考文献
Putey, Aurelien; Fournet, Guy; Joseph, Benoit
Synlett, 2006 , # 17 p. 2755 - 2758
反应条件
1: 94 percent / NaH / dimethylformamide / 15 h / 0 - 20 °C
2: 96 percent / LiOH*H2O / ethanol / 18 h / Heating
View Scheme
参考文献
Putey, Aurelien; Fournet, Guy; Joseph, Benoit
Synlett, 2006 , # 17 p. 2755 - 2758
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
T=0°C; 30 h;
参考文献
Tani, Masanobu; Ikegami, Hiroyo; Tashiro, Mayumi; Hiura, Tetsuji; Tsukioka, Hiroko; et al.
Heterocycles, 1992 , vol. 34, # 12 p. 2349 - 2362
反应条件
bromine in acetic acid
1 h; Ambient temperatureother methoxy derivatives of ethyl indole-2-acrboxylate; pyridinium bromide perbromide or N-bromosuccinimide (NBS) as bromination agent; var. solvents, temperatures and reaction times; Product distributionMechanism;
参考文献
Tani, Masanobu; Ikegami, Hiroyo; Tashiro, Mayumi; Hiura, Tetsuji; Tsukioka, Hiroko; et al.
Heterocycles, 1992 , vol. 34, # 12 p. 2349 - 2362
反应条件
bromine in acetic acid
0.00277778 h; 30 s, 24 h or 24 h with sodium acetate buffer; Product distribution;
参考文献
Kruse; Meyer
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4761 - 4768
反应条件
1: 45 percent / bromine / acetic acid / 0.01 h
2: hydrogen bromide / acetic acid / 24 h / Ambient temperature
3: 99.3 percent / aq. NaOH / ethanol; tetrahydrofuran / 1 h / Heating
View Scheme
参考文献
Kruse; Meyer
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4761 - 4768
反应条件
1: 97 percent / NaOH / ethanol / Heating
2: PCl5 / diethyl ether / 12 h / Ambient temperature
View Scheme
参考文献
Cruces, M. A.; Elorriaga, C.; Fernandez-Alvarez, E.; Lopez, O. Nieto
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 257 - 265
