(9ci)-1-乙基-1H-咪唑-4-乙胺合成路线 （共 3 条）
反应条件
hydrogenchloride in water
T=100°C; 48 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2006/125805 A1, 2006 ;
Location in patent: Page/Page column 70 ;
反应条件
1: 2-[2-(1-ethyl-1H-imidazol-4-yl)-ethyl]-isoindole-1,3-dione; 2-[2-(3-ethyl-3H-imidazol-4-yl)-ethyl]-isoindole-1,3-dione With hydrazine in ethanol
T=95°C; 1.5 h;
2: ethyl bromide in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 24.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2005/21519 A2, 2005 ;
Location in patent: Page/Page column 37 ;
WO 2005/021519 A2
反应条件
hydrogenchloride in water
8 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/87088 A2, 2003 ;
Location in patent: Page/Page column 26-27 ;
WO 03/087088 A2
