N-BOC-4-(2-乙氧羰基乙酰基)哌啶合成路线 （共 9 条）
反应条件
1: 1-(t-butoxycarbonyl)-4-(carboxy)piperidine With 1,1'-carbonyldiimidazole in acetonitrile T=20°C; 0.5 h; 2: mono-methyl malonate potassium salt With magnesium chloride in acetonitrile 2 h; Reflux;
参考文献
Asinex Limited; KAZULKIN, Denis Nikolaevich; KOCHUBEY, Valeriy Sergeevich
Patent: EP2719696 A1, 2014 ;
Location in patent: Paragraph 0221; 0222 ;
参考文献
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MEROUEH, Samy O.
Patent: WO2013/25939 A2, 2013 ;
Location in patent: Page/Page column 69; 71 ;
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; 1-(t-butoxycarbonyl)-4-(carboxy)piperidine With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane 2: ethanol Heating;
参考文献
Bashford, Katherine E.; Burton, Matthew B.; Cameron, Stuart; Cooper, Anthony L.; Hogg, Rebecca D.; Kane, Peter D.; MacManus, David A.; Matrunola, Christopher A.; Moody, Christopher J.; Robertson, Avril A. B.; Warne, Mark R.
Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1627 - 1629
反应条件
potassium tert-butylate T=0 - 20°C; 3 h; Product distribution / selectivity;
参考文献
CERENIS THERAPEUTICS SA; ONICIU, Daniela Carmen; DASSEUX, Jean-Louis Henri; BARBARAS, Ronald; KOCHUBEY, Valery; KOVALSKY, Dmitry; RODIN, Oleg Gennadievich; GEOFFROY, Otto; RZEPIELA, Anna
Patent: WO2012/54535 A2, 2012 ;
Location in patent: Page/Page column 207-209 ;
反应条件
in ethanol 48 h; Reflux;
参考文献
Mani, Timmy; Liu, Degang; Zhou, Donghui; Li, Liwei; Knabe, William Eric; Wang, Fang; Oh, Kyungsoo; Meroueh, Samy O.
ChemMedChem, 2013 , vol. 8, # 12 p. 1963 - 1977
反应条件
1: potassium carbonate / tetrahydrofuran; water / 0 - 20 °C 2: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C 3: 48 h / Reflux View Scheme
参考文献
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MEROUEH, Samy O.
Patent: WO2013/25939 A2, 2013 ;
反应条件
1: potassium carbonate / tetrahydrofuran; water / 0 - 20 °C 2: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C 3: 48 h / Reflux View Scheme
参考文献
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MEROUEH, Samy O.
Patent: WO2013/25939 A2, 2013 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C 2: 48 h / Reflux View Scheme
参考文献
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MEROUEH, Samy O.
Patent: WO2013/25939 A2, 2013 ;
反应条件
ammonium acetate in ethanol
Heating;
参考文献
Bashford, Katherine E.; Burton, Matthew B.; Cameron, Stuart; Cooper, Anthony L.; Hogg, Rebecca D.; Kane, Peter D.; MacManus, David A.; Matrunola, Christopher A.; Moody, Christopher J.; Robertson, Avril A. B.; Warne, Mark R.
Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1627 - 1629
