4-氯-7-甲苯磺酰基-7H-吡咯[2,3-D]嘧啶合成路线 （共 3 条）
反应条件
1: 4-chloro-7H-pyrrolo[2,3-d]-pyrimidine With sodium hydride in tetrahydrofuran T=20°C; 0.583333 h; 2: p-toluenesulfonyl chloride in tetrahydrofuran T=20°C; 1 h;
参考文献
WO2007/117494 A1, ;
Page/Page column 61-62 ;
WO 2007/117494 A1
反应条件
sodium hydroxide in water; acetone T=0 - 20°C; 6 h;
参考文献
WO2010/123919 A2, ;
Page/Page column 49 ;
WO 2010/123919 A2
反应条件
hydrogen iodide in water
T=0 - 20°C; 6 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/117494 A1, 2007 ;
Location in patent: Page/Page column 62 ;
WO 2007/117494 A1
