1: 1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in tetrahydrofuran T=15 - 20°C; Industry scale; 2: 3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-yloxy]-phenylamine With potassium carbonate in tetrahydrofuran T=15 - 20°C; 3 h; Industry scale;

potassium carbonate in tetrahydrofuran; water T=15 - 21°C; Industry scale;