4-(4-氯-嘧啶-2-基)-哌嗪-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
triethylamine in isopropyl alcohol 2 h; HeatingReflux;
参考文献
WO2009/145360 A1, ;
Page/Page column 116 ;
WO 2009/145360 A1
反应条件
in toluene T=110°C; regioselective reaction;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1468 - 1478
反应条件
sodium hydrogencarbonate in ethanol T=100°C; 1 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2005/176722 A1, ;
Page/Page column 20; 22 ;
反应条件
sodium hydrogencarbonate in ethanol 1.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2009/163508 A1, ;
Page/Page column 39 ;
US 20090163508 A1
