2,4,6-三羟基苯乙酮一水合物合成路线 （共 215 条）
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2: sodium hydride / N,N-dimethyl-formamide / 20 °C 3: iodine / dimethyl sulfoxide / 110 °C 4: 3,3-dimethyldioxirane / dichloromethane; acetone / 0 °C 5: hydrogen; palladium(II) oxide hydrate / tetrahydrofuran; methanol / 3 h / 20 °C View Scheme
参考文献
Yamasaki, Kazuaki; Hishiki, Ryogo; Kato, Eisuke; Kawabata, Jun
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 1 p. 17 - 21
反应条件
1: aq. KOH / ethanol / 48 h / Ambient temperature 2: 54 percent Turnov. / air, methylene blue / methanol / 81 h / Irradiation View Scheme
参考文献
Chawla, H. Mohindra; Chakrabarty, Kakoli
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1511 - 1513
反应条件
1.1: K2CO3 / acetone / 0.17 h / 20 °C 1.2: 45 percent / acetone / 24 h / Heating 2.1: ZnCl2; AcOH / 2 h / 140 - 150 °C 3.1: 84 mg / aq. NaOH; aq. H2O2 / 3 h / cooling 4.1: 82 percent / aq. HBr; acetic acid / 23 h / Heating View Scheme
参考文献
Gao, Hong; Kawabata, Jun
Bioscience, Biotechnology and Biochemistry, 2004 , vol. 68, # 9 p. 1858 - 1864
反应条件
1: 63 percent / K2CO3 / acetone / 0.5 h / Heating 2: 89 percent / KOH / ethanol; H2O / Ambient temperature 3: 80 percent / NaOAc / ethanol; H2O / 24 h / Heating 4: 92 percent / 3 N aq. HCl / methanol / 0.25 h / Heating View Scheme
参考文献
Zhao, Lianyun; Li, Yulin
Organic Preparations and Procedures International, 1996 , vol. 28, # 2 p. 165 - 171
反应条件
methanol; potassium hydroxide
参考文献
Riedl; Risse
Justus Liebigs Annalen der Chemie, 1954 , vol. 585, p. 209,219
反应条件
potassium hydroxide in water T=-10°C;
参考文献
Gupte, Amol; Buolamwini, John K.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 917 - 921
参考文献
Sonn; Buelow
Chemische Berichte, 1925 , vol. 58, p. 1697
反应条件
1: LiHMDS / THF 1) 1 h, -78 deg C 2) 2 h, -10 deg C 3) 1 h, -78 deg C 4) 16 h, r.t. 2: 76 percent / 0.5percent H2SO4 / acetic acid / 1 h / 95 - 100 °C View Scheme
参考文献
Wang, Jin; Zhou, Rong-Guang; Wu, Ting; Yang, Tao; Qin, Qi-Xue; Li, Li; Yang, Bo; Yang, Jian
Journal of Chemical Research, 2012 , vol. 36, # 3 p. 121 - 122
反应条件
1: 2',4',6'-trihydroxyacetophenone With potassium carbonate in tetrahydrofuran T=20 - 50°C; 1 h; 2: acetyl chloride in tetrahydrofuran 4 h; Heating / reflux; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
MERCK PATENT GMBH
Patent: WO2005/19197 A1, 2005 ;
Location in patent: Page/Page column 50; 51 ;
反应条件
sodium acetate; acetic anhydride
参考文献
Shinoda
Yakugaku Zasshi, 1928 , vol. 48, p. 35
Chem. Zentralbl., 1928 , vol. 99, # II p. 50
