2,4,6-三羟基苯乙酮一水合物合成路线 （共 215 条）
反应条件
in toluene T=40°C; 72 h;
参考文献
Apsimon, J. W.; Herman, L. W.; Huber, C.
Canadian Journal of Chemistry, 1985 , vol. 63, p. 2589 - 2596
反应条件
1: With acetic anhydride T=180°C; 0.666667 h; Microwave irradiation; 2: With potassium carbonate in water 2 h; Reflux;
参考文献
Bruder, Marjorie; Haseler, Paul L.; Muscarella, Marina; Lewis, William; Moody, Christopher J.
Journal of Organic Chemistry, 2010 , vol. 75, # 2 p. 353 - 358
反应条件
sodium acetate Erwaermen des Reaktionsprodukts mit wss.-aethanol. Natriumcarbonat-Loesung;
参考文献
Murti; Seshadri
Proceedings - Indian Academy of Sciences, Section A, 1949 , # 30 p. 107,112
反应条件
1: LiHMDS / THF 1) 1 h, -78 deg C 2) 2 h, -10 deg C 3) 1 h, -78 deg C 4) 16 h, r.t. 2: 82 percent / 0.5percent H2SO4 / acetic acid / 1 h / 95 - 100 °C View Scheme
参考文献
Ninomiya, Masayuki; Tanaka, Kaori; Tsuchida, Yuzo; Muto, Yoshinori; Koketsu, Mamoru; Watanabe, Kunitomo
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1529 - 1536
反应条件
1: 92 percent / K2CO3 / acetone / 3 h / 65 °C 2: 60 percent / aluminium chloride / chlorobenzene / 1 h / Heating 3: 99 percent / K2CO3 / acetone / Heating 4: 29 percent / NaOH; K2S2O8; pyridine / H2O / 24 h / 20 °C 5: 59 percent / K2CO3 / acetone / Heating 6: pyridine / 3 h / 20 °C 7: KOH / pyridine / 4 h / 60 °C 8: sulfuric acid / acetic acid / 1.5 h / 60 °C 9: BCl3 / CH2Cl2 / 1.5 h / -65 °C View Scheme
参考文献
British Journal of Pharmacology, , vol. 142, # 5 p. 811 - 820
反应条件
1: potassium carbonate / acetone / 4 h / 20 °C 2: potassium carbonate / acetone / 8 h / 20 °C 3: pyridine; potassium hydroxide / 1 h / 50 °C View Scheme
参考文献
Hu, Kun; Wang, Wei; Cheng, Hong; Pan, ShaSha; Ren, Jie
Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 838 - 846
反应条件
potassium carbonate; potassium iodide in 1,4-dioxane 24 h; Heating; Yields of byproduct given;
参考文献
Gissaub, M. Amzad; Tarafdar
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998 , vol. 37, # 6 p. 540 - 543
反应条件
potassium carbonate; potassium iodide in 1,4-dioxane 24 h; Heating;
参考文献
Hossain, M. Amzad
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2001 , vol. 40, # 2 p. 93 - 95
反应条件
1: With pyridine T=20°C; 2: With sodium carbonate in ethanol T=60 - 70°C; 2 h; Further stages.;
参考文献
Choi, Seoung-Ryoung; Pradhan, Anupam; Hammond, Nicholas L.; Chittiboyina, Amar G.; Tekwani, Babu L.; Avery, Mitchell A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 16 p. 3841 - 3850
反应条件
1: pyridine / 20 °C 2: 5 percent aq. Na2CO3 / ethanol / 2 h / 60 - 70 °C View Scheme
参考文献
Spencer, Gayland F.
Organic Preparations and Procedures International, 1991 , vol. 23, # 3 p. 390 - 392
