2,4,6-三羟基苯乙酮一水合物合成路线 （共 215 条）
反应条件
1: potassium carbonate / acetone / 20 °C
2: potassium carbonate / acetone / Reflux
3: sodium acetate; acetic acid / Reflux
View Scheme
参考文献
Zheng, Xing; Zhao, Fei Fei; Liu, Yun Mei; Yao, Xu; Zheng, Zi Tong; Luo, Xing; Liao, Duan Fang
Medicinal Chemistry, 2010 , vol. 6, # 1 p. 6 - 8
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.25 h / -78 °C / |Inert atmosphere
1.2: 5.17 h / -78 - 20 °C / |Inert atmosphere
2.1: potassium carbonate / acetone / 4 h / |Reflux
View Scheme
参考文献
Li, Su-Yi; Wang, Xiao-Bing; Xie, Sai-Sai; Jiang, Neng; Wang, Kelvin D.G.; Yao, He-Quan; Sun, Hong-Bin; Kong, Ling-Yi
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 632 - 646
反应条件
sodium 4-methoxyphenylacetate
T=180°C;
参考文献
Kogure
Nippon Kagaku Zasshi, 1952 , vol. 73, p. 308
Chem.Abstr., 1953 , p. 10527
Full Text Show Details
Kogure; Kubota
Journal of the Institute of Polytechnics, Osaka City University, Series C: Chemistry, 1951 , vol. <C> 2, p. 76,80
Full Text Show Details
Simpson; Garden
Journal of the Chemical Society, 1952 , p. 4638,4643
反应条件
1: pyridine / 2 h
2: K2CO3, pyridine / 3 h / Heating
3: H2SO4, CH3CO2H
View Scheme
参考文献
Cardoso, Ana M.; Silva, Artur M. S.; Barros, Cristina M. F.; Almeida, Lucia M. P. M.; Ferrer-Correia; Cavaleiro, Jose A. S.
Journal of Mass Spectrometry, 1997 , vol. 32, # 9 p. 930 - 939
反应条件
1.1: K2CO3 / acetone / 0.17 h / 20 °C
1.2: 45 percent / acetone / 24 h / Heating
2.1: ZnCl2; AcOH / 2 h / 140 - 150 °C
3.1: 84 mg / aq. NaOH; aq. H2O2 / 3 h / cooling
View Scheme
参考文献
Gao, Hong; Kawabata, Jun
Bioscience, Biotechnology and Biochemistry, 2004 , vol. 68, # 9 p. 1858 - 1864
反应条件
sodium methylate in methanol
Reflux;
参考文献
Nakagawa-Goto, Kyoko; Bastow, Kenneth F.; Chen, Tzu-Hsuan; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung
Journal of Medicinal Chemistry, 2008 , vol. 51, # 11 p. 3297 - 3303
反应条件
potassium methanolate in methanol; diethyl ether
参考文献
Nowy,G. et al.
Chemische Berichte, 1966 , vol. 99, p. 2075 - 2082
反应条件
1.1: KI; K2CO3; CuI / acetone / 3 h / Heating
1.2: 40 percent / N,N-dimethylaniline / dimethylformamide / 2 h / 140 °C
2.1: 90 percent / KOH / ethanol; H2O / 6 h / 20 °C
View Scheme
参考文献
Deodhar, Mandar; Black, David St.C.; Kumar, Naresh
Organic Preparations and Procedures International, 2006 , vol. 38, # 1 p. 94 - 99
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Anthoni, Uffe; Encarnacion D., Rosalba; Nielsen, Per H.; Christophersen, Garsten
Acta Chemica Scandinavica, 1998 , vol. 52, # 10 p. 1243 - 1246
反应条件
1: 11.5 g
2: 4.6 g / K2S2O8
View Scheme
参考文献
Iinuma; Iwashima; Matsuura
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4935 - 4941
