2,4,6-三羟基苯乙酮一水合物合成路线 （共 215 条）
反应条件
1: 11.5 g
2: 4.6 g / K2S2O8
3: 1.9 g / partial methylation
View Scheme
参考文献
Iinuma; Iwashima; Matsuura
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4935 - 4941
反应条件
1: 1.6 g / BF3*Et2O, MeSO2Cl / dimethylformamide / 2 h / 50 °C
2: 300 mg / BF3*Et2O / dioxane / 10 h / 40 - 45 °C
View Scheme
参考文献
Jain, A. C.; Gupta, S. M.; Tyagi, O. D.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 11 p. 1036 - 1039
反应条件
potassium hydroxide in ethanol
48 h; Ambient temperature;
参考文献
Pare, Paul W.; Mischke, Charles F.; Edwards, Robert; Dixon, Richard A.; Norman, Helen A.; Mabry, Tom J.
Phytochemistry (Elsevier), 1992 , vol. 31, # 1 p. 149 - 154
反应条件
1: potassium carbonate / acetone
2: potassium hydroxide / ethanol
3: hydrogenchloride / methanol; water / 0.5 h / Reflux
View Scheme
参考文献
Guan, Li-Ping; Zhao, Dong-Hai; Chang, Yue; Sun, Yu; Ding, Xiao-Li; Jiang, Jing-Fei
Medicinal Chemistry Research, 2013 , vol. 22, # 11 p. 5218 - 5226
反应条件
1: sodium-<2-methoxy benzoate / 180 °C / unter vermindertem Druck und kurzem Erwaermen des Reaktionsprodukts mit wss.-aethanol. Alkalilauge
2: aqueous sodium carbonate-solution
3: acetone; potassium carbonate
View Scheme
参考文献
Zheng, Xing; Zhao, Fei Fei; Liu, Yun Mei; Yao, Xu; Zheng, Zi Tong; Luo, Xing; Liao, Duan Fang
Medicinal Chemistry, 2010 , vol. 6, # 1 p. 6 - 8
反应条件
1: 2',4',6'-trihydroxyacetophenone With potassium carbonate in acetone
T=20°C; 0.166667 h;
2: 3,4,5-trimethoxy-benzoic acid chloride in acetone
24 h; Heating;
参考文献
Gao, Hong; Kawabata, Jun
Bioscience, Biotechnology and Biochemistry, 2004 , vol. 68, # 9 p. 1858 - 1864
反应条件
sodium 3,4,5-trimethoxybenzoate
T=175°C; anschliessend Erwaermen mit wss.-aethanol. Kalilauge und Erwaermen des Reaktionsprodukts mit Essigsaeure;
参考文献
Rao et al.
Proceedings - Indian Academy of Sciences, Section A, 1949 , # 29 p. 72,75
Full Text Show Details
Anderson
Canadian Journal of Research, 1932 , vol. 7, p. 285,289
Full Text Show Details
Badhwar; Kang; Venkataraman
Journal of the Chemical Society, 1932 , p. 1107,1108
反应条件
sodium 3,4,5-trimethoxybenzoate
T=175°C; Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge;
参考文献
Anderson
Canadian Journal of Research, 1932 , vol. 7, p. 285,289
反应条件
1: 2',4',6'-trihydroxyacetophenone With potassium carbonate in acetone
T=20°C; 0.166667 h;
2: 3,4-dimethoxybenzoic acid chloride in acetone
24 h; Heating;
参考文献
Gao, Hong; Kawabata, Jun
Bioscience, Biotechnology and Biochemistry, 2004 , vol. 68, # 9 p. 1858 - 1864
反应条件
1: saturated aq. potassium carbonate / benzene / 0.33 h / 60 °C
2: tetrabutylammonium hydrogen sulfate / benzene; H2O / 3 h / 60 °C
3: 1.) 5percent aq. potassium carbonate, 2.) glacial acetic acid / 1.) reflux, 4 h, 2.) 5 min
View Scheme
参考文献
Saxena, Shabnam; Makrandi, J. K.; Grover, S. K.
Synthesis, 1985 , # 6/7 p. 697
