2,4,6-三羟基苯乙酮一水合物合成路线 （共 215 条）
反应条件
sodium 3,4-dimethoxybenzoate
T=180°C; unter vermindertem Druck; anschliessendes Erwaermen mit aethanol. Kalilauge;
参考文献
Rao et al.
Proceedings - Indian Academy of Sciences, Section A, 1949 , # 29 p. 72,75
反应条件
1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / dichloromethane; water
2: ethylenediamine diacetic acid / xylenes
View Scheme
参考文献
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Patent: US2011/112182 A1, 2011 ;
US 20110112182 A1
反应条件
1: 1.) polyphosphoric acid, 2.) potassium carbonate / 1.) dioxane, 60 deg C, 3 h, 2.) acetone, reflux, 50 h
2: 64 percent / potassium carbonate / acetone / 2 h / Heating
3: 93 percent / potassium carbonate / acetone / 4 h / Heating
4: 70 percent / NaBH4, PdCl2 / tetrahydrofuran; H2O / 1.5 h / 0 - 5 °C
5: 92 percent / toluene-p-sulfonic acid / toluene / 0.33 h / Heating
6: 95 percent / potassium carbonate / methanol / 1.5 h / Heating
View Scheme
参考文献
Donnelly, Dervilla M. X.; Molloy, David J.; Reilly, John P.; Finet, Jean-Pierre
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 20 p. 2531 - 2534
反应条件
1: 1.) polyphosphoric acid, 2.) potassium carbonate / 1.) dioxane, 60 deg C, 3 h, 2.) acetone, reflux, 50 h
2: 64 percent / potassium carbonate / acetone / 2 h / Heating
3: 93 percent / potassium carbonate / acetone / 4 h / Heating
4: 70 percent / NaBH4, PdCl2 / tetrahydrofuran; H2O / 1.5 h / 0 - 5 °C
5: 92 percent / toluene-p-sulfonic acid / toluene / 0.33 h / Heating
6: 95 percent / potassium carbonate / methanol / 1.5 h / Heating
7: 80 percent / sodium hydride / 0.5 h / 45 °C
8: 79 percent / pyridine / CHCl3 / 14 h / 60 °C
View Scheme
参考文献
Donnelly, Dervilla M. X.; Molloy, David J.; Reilly, John P.; Finet, Jean-Pierre
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 20 p. 2531 - 2534
反应条件
1: anhydr. K2CO3 / acetone / 0.5 h / 50 - 60 °C
2: (C2H5)3SiH / trifluoroacetic acid / 20 °C
3: BF3*Et2O
View Scheme
参考文献
Mateeva, Nelly N.; Kode, Rao N.; Redda, Kinfe K.
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 6 p. 1251 - 1258
反应条件
1: 1.50 g / K2CO3 / acetone / 5 h / Heating
2: 400 mg / ethanol; aq. NaOH / 80 h / Ambient temperature
3: 220 mg / SeO2 / pentan-1-ol
View Scheme
参考文献
Zheng, Xing; Zhao, Fei Fei; Liu, Yun Mei; Yao, Xu; Zheng, Zi Tong; Luo, Xing; Liao, Duan Fang
Medicinal Chemistry, 2010 , vol. 6, # 1 p. 6 - 8
反应条件
1: POCl3 / ethyl acetate / 0.5 h / 20 °C
2: potassium hydroxide / methanol / 2 h / Heating
View Scheme
参考文献
Bharate, Sandip B.; Chauthe, Siddheshwar K.; Bhutani, Kamlesh K.; Singh, Inder P.
Australian Journal of Chemistry, 2005 , vol. 58, # 7 p. 551 - 555
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Yepremyan, Akop; Salehani, Baback; Minehan, Thomas G.
Organic Letters, 2010 , vol. 12, # 7 p. 1580 - 1583
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
T=20 - 80°C; 1 - 7 h;
2: With hydrogenchloride; water in N,N-dimethyl-formamide
Product distribution / selectivity;
参考文献
MARS, INCORPORATED
Patent: WO2007/2877 A1, 2007 ;
Location in patent: Page/Page column 7; 21-23 ;
反应条件
1.1: pyridine / 1.25 h / 20 °C
2.1: pyridine; potassium hydroxide / 1 h / 50 °C
2.2: pH 6
3.1: water; potassium carbonate / Reflux
View Scheme
参考文献
Chang, Liu-Shuan; Li, Chun-Bao; Qin, Nan; Jin, Mei-Na; Duan, Hong-Quan
Chemistry and Biodiversity, 2012 , vol. 9, # 1 p. 162 - 169
