2,4,6-三羟基苯乙酮一水合物合成路线 （共 215 条）
反应条件
1: 55 percent / DBU / pyridine / 7 h / 80 - 90 °C 2: 53 percent / KOH / H2O / Heating View Scheme
参考文献
Saxena, Shabnam; Makrandi, J. K.; Grover, S. K.
Synthesis, 1985 , # 6/7 p. 697
反应条件
anhydrous sodium benzoate T=180 - 185°C; Verseifen des Reaktionsprodukts mit waessrig-alkoholischer Kalilauge;
参考文献
Robinson; Venkataraman
Journal of the Chemical Society, 1926 , p. 2346
反应条件
anhydrous sodium benzoate T=180 - 185°C;
参考文献
Gulati; Venkataraman
Journal of the Chemical Society, 1936 , p. 267
反应条件
1: 84 percent / N,N-diisopropylethylamine / CH2Cl2 / 0 - 20 °C 2: 100 percent / K2CO3 / dimethylformamide / 3 h / 80 °C 3: 100 percent / HCl / methanol / 1 h / Heating 4: 84 percent / K2CO3 / dimethylformamide / 0 - 20 °C 5: 75 percent / 4 Angstroem molecular sieves; BF3*Et2O / CH2Cl2 / -78 - 20 °C 6: 100 percent / K2CO3 / dimethylformamide / 3 h / 80 °C 7: 40 percent / H2 / Pd/C / ethyl acetate / 2 h / 20 °C 8: 91 percent / NaOH / dioxane; H2O / 24 h / 20 °C 9: 76 percent / I2 / dimethylsulfoxide / 0.25 h / 200 °C 10: 100 percent / H2 / Pd/C / ethyl acetate; ethanol / 4.5 h / 20 °C View Scheme
参考文献
Kumazawa, Toshihiro; Minatogawa, Tomomi; Matsuba, Shigeru; Sato, Shingo; Onodera, Jun-Ichi
Carbohydrate Research, 2000 , vol. 329, # 3 p. 507 - 513
反应条件
1: potassium carbonate / acetone / 0 - 20 °C 2: potassium hydroxide / ethanol 3: sodium acetate / ethanol / Reflux 4: hydrogenchloride / methanol; water / 0.5 h / Reflux View Scheme
参考文献
Zhao, Dong-Hai; Sui, Xin; Qu, You-Le; Yang, Li-Ye; Wang, Xian; Guan, Li-Ping
Asian Journal of Chemistry, 2011 , vol. 23, # 3 p. 1129 - 1132
反应条件
1: pyridinium p-toluenesulfonate / CH2Cl2 / Ambient temperature 2: Ba(OH)2*8H2O / methanol / 12 h / 40 °C 3: p-TsOH / methanol / 3 h / Ambient temperature View Scheme
参考文献
Sogawa; Nihro; Ueda; Izumi; Miki; Matsumoto; Satoh
Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3904 - 3909
反应条件
potassium carbonate in acetone T=0°C; 9.08 h;
参考文献
Hawranik, Drew J.; Anderson, Kurtis S.; Simmonds, Reesa; Sorensen, John. L.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 9 p. 2383 - 2385
参考文献
Riedl; Risse
Justus Liebigs Annalen der Chemie, 1954 , vol. 585, p. 209,219
Full Text Show Details
Riedl et al.
Chemische Berichte, 1956 , vol. 89, p. 1849,1854
Full Text Show Details
Obata; Horitsu
Bulletin of the Agricultural Chemical Society of Japan, 1959 , vol. 23, p. 186,190
反应条件
Reaktion mit:weiteres Produkt:1-<2,4,6-Trihydroxy-3,5-dimethyl-phenyl>-aethanon.Reaktion mit:Produkt5: 1-<2,4,6-Trihydroxy-3-methyl-phenyl>-aethanon.;
参考文献
Riedl; Huebner
Chemische Berichte, 1957 , vol. 90, p. 2870,2875
反应条件
sodium chloride; potassium carbonate in tetrahydrofuran
参考文献
Tsumura and Co.
Patent: US5106871 A1, 1992 ;
