(2,4-二氧代-3,4-二氢喹唑啉-1(2H)-基)乙酸合成路线 （共 10 条）
反应条件
1: 1H,3H-quinazoline-2,4-dione With lithium hydroxide hydrate in dimethyl sulfoxide
T=40°C; 2 h;
2: monobromoacetic acid in dimethyl sulfoxide
T=40°C; 12 h;
3: With hydrogenchloride in water
pH=2; Reagent/catalyst; regioselective reaction;
参考文献
Li, Pengfa; Zhan, Chuanlang; Zhang, Shanlin; Ding, Xunlei; Guo, Fengqi; He, Shenggui; Yao, Jiannian
Tetrahedron, 2012 , vol. 68, # 43 p. 8908 - 8915
反应条件
hydrogenchloride; potassium hydroxide in ethanol; water
1 h; Heating;
参考文献
Suesse, Manfred; Johne, Siegfried
Monatshefte fuer Chemie, 1987 , vol. 118, p. 71 - 80
反应条件
hydrogenchloride; potassium hydroxide in ethanol; water
1 h; Heating;
参考文献
Suesse, Manfred; Johne, Siegfried
Monatshefte fuer Chemie, 1987 , vol. 118, p. 71 - 80
反应条件
1: 4 h / Heating
2: 1) KOH, 2) HCl / ethanol; H2O / 2 h / Heating
View Scheme
参考文献
Suesse, Manfred; Johne, Siegfried
Monatshefte fuer Chemie, 1987 , vol. 118, p. 71 - 80
反应条件
hydrogenchloride; potassium hydroxide in ethanol; water
2 h; Heating;
参考文献
Suesse, Manfred; Johne, Siegfried
Monatshefte fuer Chemie, 1987 , vol. 118, p. 71 - 80
反应条件
1: 62 percent / urea / dimethylformamide / 5 h / Heating
2: 73 percent / 1) KOH, 2) HCl / ethanol; H2O / 1 h / Heating
View Scheme
参考文献
Suesse, Manfred; Johne, Siegfried
Monatshefte fuer Chemie, 1987 , vol. 118, p. 71 - 80
反应条件
1: 19 percent / acetic acid / 3 h / Heating
2: 73 percent / 1) KOH, 2) HCl / ethanol; H2O / 1 h / Heating
View Scheme
参考文献
Suesse, Manfred; Johne, Siegfried
Monatshefte fuer Chemie, 1987 , vol. 118, p. 71 - 80
反应条件
1: 4 h / Heating
2: 1) KOH, 2) HCl / ethanol; H2O / 2 h / Heating
View Scheme
参考文献
Suesse, Manfred; Johne, Siegfried
Monatshefte fuer Chemie, 1987 , vol. 118, p. 71 - 80
反应条件
1: 65 percent / urea / dimethylformamide / 5 h / Heating
2: 73 percent / 1) KOH, 2) HCl / ethanol; H2O / 1 h / Heating
View Scheme
参考文献
Suesse, Manfred; Johne, Siegfried
Monatshefte fuer Chemie, 1987 , vol. 118, p. 71 - 80
反应条件
1.1: neat (no solvent) / 12 h / 150 °C
2.1: lithium hydroxide hydrate / dimethyl sulfoxide / 2 h / 40 °C
2.2: 12 h / 40 °C
2.3: pH 2
View Scheme
参考文献
Li, Pengfa; Zhan, Chuanlang; Zhang, Shanlin; Ding, Xunlei; Guo, Fengqi; He, Shenggui; Yao, Jiannian
Tetrahedron, 2012 , vol. 68, # 43 p. 8908 - 8915
