4-溴-2-碘-N-对甲苯磺酰-7-氮杂吲哚合成路线 （共 3 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=130°C; 10 h; Microwave irradiation;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/49855 A2, 2008 ;
Location in patent: Page/Page column 59-60 ;
WO 2008/049855 A2
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=120°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/67119 A2, 2008 ;
Location in patent: Page/Page column 29; 39 ;
WO 2008/067119 A2
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes
T=-78 - 0°C; 1.5 h;
2: With iodine in tetrahydrofuran; hexanes
T=-78°C; 0.333333 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/145688 A2, 2008 ;
Location in patent: Page/Page column 42; 90 ;
WO 2008/145688 A2
