4-乙氧基-3-甲酰基苯硼酸合成路线 (共 2 条)
反应条件
1: With n-butyllithium in diethyl ether; hexane
T=-78°C; 0.666667 h;
2: With boron triethoxide in diethyl ether; hexane
T=-78°C; 4.16667 h;
3: With hydrogenchloride; water in diethyl ether; hexane
T=20°C; 17.5 h; Heating / reflux;
参考文献
WYETH
Patent: WO2007/89669 A2, 2007 ;
Location in patent: Page/Page column 118 ;
反应条件
1: C11H15BrO3 With n-butyllithium in hexanes; diethyl ether
T=-78°C; 0.666667 h;
2: boron triethoxide in hexanes; diethyl ether
T=-78°C; 4.16667 h;
3: With hydrogenchloride; water in hexanes; diethyl ether
T=-78 - 20°C; 16 h; Heating / reflux;
参考文献
CURIS, INC.
Patent: WO2008/57497 A2, 2008 ;
Location in patent: Page/Page column 205 ;