5-氯-N,N-二甲基-2-硝基苄胺合成路线 （共 6 条）
反应条件
triethylamine in tetrahydrofuran
T=20°C; Reflux;
参考文献
PFIZER INC.; CONN, Edward Lee; HEPWORTH, David; QI, Yingmei; ROCKE, Benjamin Neil; RUGGERI, Roger Benjamin; ZHANG, Yan
Patent: WO2011/145022 A1, 2011 ;
Location in patent: Page/Page column 64 ;
参考文献
Montagne
Recueil des Travaux Chimiques des Pays-Bas, 1900 , vol. 19, p. 55
反应条件
1-ethyl-3-(3-dimethylaminopyridyl)carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine in N,N-dimethyl-formamide
参考文献
Hagiwara, Atsushi; Ikenogami, Taku; Kurihara, Kazunori; Taniguchi, Toshio; Takahashi, Mitsuru; Ida, Akio
Patent: US2006/89392 A1, 2006 ;
Location in patent: Page/Page column 82 ;
反应条件
1: PCl5
2: diethyl ether
View Scheme
参考文献
Montagne
Recueil des Travaux Chimiques des Pays-Bas, 1900 , vol. 19, p. 55
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C
1.2: 3 h / 120 °C
2.1: hydrogenchloride; water / 3 h / Reflux
3.1: acetyl chloride / 3 h / 0 - 20 °C
4.1: hydrogen / 5 palladium on charcoal / toluene; tetrahydrofuran / 20 °C / 37503.8 Torr
View Scheme
参考文献
PFIZER INC.; CONN, Edward Lee; HEPWORTH, David; QI, Yingmei; ROCKE, Benjamin Neil; RUGGERI, Roger Benjamin; ZHANG, Yan
Patent: WO2011/145022 A1, 2011 ;
反应条件
anhydrous iron chloride; zinc in DMF (N,N-dimethyl-formamide); water
0.333333 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1405852 A1, 2004 ;
Location in patent: Page 226-227 ;
EP 1405852 A1
