3-溴-2-甲基咪唑并[1,2-A]吡啶合成路线 （共 4 条）
反应条件
1: With bromine; acetic acid
0.0833333 h;
2: With sodium hydroxide in water; ethyl acetate
pH=10;
参考文献
AMGEN INC.; BO, Yunxin, Y.; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark, H.; SIEGMUND, Aaron, C.; TAMAYO, Nuria, A.; YANG, Kevin
Patent: WO2010/108074 A2, 2010 ;
Location in patent: Page/Page column 43-44 ;
WO 2010/108074 A2
反应条件
hydrogenchloride; sodium hydrogencarbonate in tetrahydrofuran; ethanol; chloroform; ethyl acetate
参考文献
Roussel-UCLAF
Patent: US5420138 A1, 1995 ;
US 5420138 A
反应条件
1: copper(l) iodide; triethylamine / N,N-dimethyl-formamide
2: N-bromosuccinmide / |Inert atmosphere
View Scheme
参考文献
Patnaik, Samarjit; Marugan, Juan J.; Liu, Ke; Zheng, Wei; Southall, Noel; Dehdashti, Seameen J.; Thorsell, Annika; Heilig, Markus; Bell, Lauren; Zook, Michelle; Eskay, Bob; Brimacombe, Kyle R.; Austin, Christopher P.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9045 - 9056
反应条件
1: ethanol / 2 h / |Inert atmosphere; |Reflux
2: copper(l) iodide; triethylamine / N,N-dimethyl-formamide
3: N-bromosuccinmide / |Inert atmosphere
View Scheme
参考文献
Patnaik, Samarjit; Marugan, Juan J.; Liu, Ke; Zheng, Wei; Southall, Noel; Dehdashti, Seameen J.; Thorsell, Annika; Heilig, Markus; Bell, Lauren; Zook, Michelle; Eskay, Bob; Brimacombe, Kyle R.; Austin, Christopher P.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9045 - 9056
