反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice; Inert atmosphere 2: potassium tert-butylate / tetrahydrofuran / 1 h / Reflux; Inert atmosphere 3: toluene-4-sulfonic acid / benzene / 7 h / Reflux; Inert atmosphere 4: 20 palladium hydroxide on charcoal; hydrogen / ethanol; ethyl acetate / 2 h / 20 °C / Inert atmosphere 5: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 23 p. 7085 - 7092