1,4-二羟基-2-甲基萘合成路线 （共 60 条）
反应条件
sodium hydride in N,N-dimethyl-formamide; mineral oil
T=-10°C; 2 h;
参考文献
Bachmann, Daniel G.; Wittwer, Christopher C.; Gillingham, Dennis G.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3703 - 3707
参考文献
Laatsch
1983 , vol. No. 2, p. 299 - 315
反应条件
1: NaOH / methanol
2: 95 percent / NBS / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Jung, Young-Sik; Joe, Bo-Young; Cho, Sung Ju; Konishi, Yasuo
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1125 - 1129
反应条件
1.) ether, 15 h, 0 deg C; Multistep reaction. Further byproducts given;
参考文献
Laatsch, Hartmut
Liebigs Annalen der Chemie, 1984 , # 7 p. 1367 - 1381
反应条件
1: ZnCl2; ether BF3 / anschliessend mit Ag2O behandeln
2: zinc-powder
View Scheme
参考文献
Isler et al.
Helvetica Chimica Acta, 1958 , vol. 41, p. 786,802
反应条件
1: 98 percent / sodium methylate / methanol; propan-2-ol / 0.5 h / 63 °C
2: TiCl4 / CH2Cl2 / 2 h / 0 °C
3: 59 percent / t-BuONa / toluene / 3 h / 60 °C
View Scheme
参考文献
Ito, Tatsuya; Ikemoto, Tomomi; Yamano, Toru; Mizuno, Yukio; Tomimatsu, Kiminori
Tetrahedron Asymmetry, 2003 , vol. 14, # 22 p. 3525 - 3531
反应条件
hydrogenchloride; amalgamated zinc
参考文献
Madinaveitia
Anales de la Real Sociedad Espanola de Fisica y Quimica, 1934 , vol. 32, p. 1100,1105
Chem. Zentralbl., 1935 , vol. 106, # I p. 3134
参考文献
Ansbacher; Fernholz; Dolliver
Journal of the American Chemical Society, 1940 , vol. 62, p. 155,156
参考文献
Merck,E.
Patent: DE734220 , 1940 ;
DRP/DRBP Org.Chem.
参考文献
Fieser et al.
Journal of the American Chemical Society, 1939 , vol. 61, p. 3216,3220
