2-(2-硝基苯基)-1,3-二氧戊环合成路线 （共 10 条）
反应条件
aluminium trichloride; silver(I) bromate in acetonitrile 1.5 h; Heating;
参考文献
Synthesis, , # 3 p. 487 - 490
反应条件
palladium 10 on activated carbon; hydrogen; triethylamine in isopropyl alcohol 18 h;
参考文献
Clayden, Jonathan; Pickworth, Mark; Jones, Lyn H.
Chemical Communications, 2009 , # 5 p. 547 - 549
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 14 p. 2672 - 2687
反应条件
n-butyltriphenylphosphonium peroxodisulfate in acetonitrile 2.5 h; Heating;
参考文献
Mohammadpoor-Baltork; Hajipour; Aghajari
Synthetic Communications, 2002 , vol. 32, # 9 p. 1311 - 1317
反应条件
tetra-n-butylammonium tribromide in tetrahydrofuran T=20°C; 0.75 h;
参考文献
Naik, Sarala; Gopinath, Rangam; Goswami, Mousumi; Patel, Bhisma K.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 11 p. 1670 - 1677
反应条件
toluene-4-sulfonic acid in toluene
T=20°C; RefluxInert atmosphere;
参考文献
Clayden, Jonathan; Pickworth, Mark; Jones, Lyn H.
Chemical Communications, 2009 , # 5 p. 547 - 549
反应条件
potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide
T=-60°C; 1.5 h;
参考文献
Barbasiewicz, Michal; Makosza, Mieczyslaw
Organic Letters, 2006 , vol. 8, # 17 p. 3745 - 3748
反应条件
1: With copper(l) iodide in N,N-dimethyl-formamide
T=100°C; Dehalogenation; arylation; 6 h;
2: With sodium hydroxide in N,N-dimethyl-formamide
T=20°C; Deacetylation; 16 h;
参考文献
Sobrio; Amokhtari; Gourand; Dhilly; Dauphin; Barre
Bioorganic and medicinal chemistry, 2000 , vol. 8, # 10 p. 2511 - 2518
反应条件
1: HNO3; H2SO4 / CH2Cl2 / 6 h / 20 °C
2: amberlite IR 120 (nuclear sulfonic acid type) / benzene / 6 h / 80 °C
View Scheme
参考文献
Sainz-Diaz
Monatshefte fur Chemie, 2002 , vol. 133, # 1 p. 9 - 22
反应条件
1: H2 / 10 percent Pd/C / ethyl acetate
2: pyridine / CH2Cl2
View Scheme
参考文献
Meanwell; Pearce; Roth; Smith; Wedding; Wright; Buchanan; Baryla; Gamberdella; Gillespie; Hayes; Seiler; Stanton; Zavoico; Fleming
Journal of Medicinal Chemistry, 1992 , vol. 35, # 14 p. 2672 - 2687
