2-氨基-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺合成路线 （共 18 条）
参考文献
Briel; Rybak; Kronbach; Unverferth
Pharmazie, 2008 , vol. 63, # 11 p. 823 - 826
参考文献
Romashov, Leonid V.; Zeifman, Alexey A.; Zakharenko, Alexandra L.; Novikov, Fedor N.; Stroilov, Viktor S.; Stroganov, Oleg V.; Chilov, Germes G.; Khodyreva, Svetlana N.; Lavrik, Olga I.; Titov, Ilya Yu.; Svitan'Ko, Igor V.
Mendeleev Communications, 2012 , vol. 22, # 1 p. 15 - 17
→
27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮
参考文献
Sauter,F.
Monatshefte fuer Chemie, 1970 , vol. 101, p. 535 - 543
→
27285-09-21,2,3,4,5,6,7,8-八氢苯并[4,5]噻吩并[2,3-d]嘧啶-2,4-二酮
反应条件
T=160 - 190°C; 0.5 h;
参考文献
Gakhar,H.K. et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1978 , vol. 16B, p. 940 - 942
反应条件
thionyl chloride in tetrahydrofuran
参考文献
Wamhoff, Heinrich; Ertas, Muemtaz
Synthesis, 1985 , # 2 p. 190 - 194
反应条件
1: 71 percent / pyridine / benzene
2: 82 percent / polyphosphate ester / 8 h / Heating
View Scheme
参考文献
Kanwar, Seema; Sharma
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2367 - 2371
反应条件
1: With hydrogenchloride in water; acetic acid
T=5 - 20°C;
2: With sodium nitrite in water; acetic acid
T=0 - 5°C;
参考文献
Saravanan, Janardhanan; Mohan, Shamanna; Roy, Jay Jyoti
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 4365 - 4369
参考文献
Arya,V.P.
Indian Journal of Chemistry, 1972 , vol. 10, p. 1141 - 1150
