5-氨基-3-甲基-2,4-噻酚二羧酸二乙酯合成路线 （共 9 条）
反应条件
morpholine; aluminum oxide; sulfur 0.166667 h; microwave irradiation;
参考文献
Mobinikhaledi; Kalhor; Taheri
Asian Journal of Chemistry, 2010 , vol. 22, # 9 p. 7399 - 7404
反应条件
1: ethylenediammonium diacetate / 0.25 h / microwave irradiation 2: EtONa / ethanol / 0.08 h / microwave irradiation View Scheme
参考文献
Hu, Yi; Wei, Ping; Huang, He; Han, Shi-Qing; Ouyang, Ping-Kai
Synthetic Communications, 2006 , vol. 36, # 11 p. 1543 - 1548
反应条件
hydrogenchloride in water 0.666667 h; Microwave irradiation;
参考文献
Jain, Kishor S.; Bariwal, Jitender B.; Phoujdar, Manisha S.; Nagras, Madhuri A.; Amrutkar, Rakesh D.; Munde, Manoj K.; Tamboli, Riyaj S.; Khedkar, Samrat A.; Khiste, Rahul H.; Vidyasagar, Nikhil C.; Dabholkar, Vinit V.; Kathiravan
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 178 - 185
反应条件
hydrogenchloride in water 0.166667 h; Microwave irradiation;
参考文献
Jain, Kishor S.; Bariwal, Jitender B.; Phoujdar, Manisha S.; Nagras, Madhuri A.; Amrutkar, Rakesh D.; Munde, Manoj K.; Tamboli, Riyaj S.; Khedkar, Samrat A.; Khiste, Rahul H.; Vidyasagar, Nikhil C.; Dabholkar, Vinit V.; Kathiravan
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 178 - 185
反应条件
trichlorophosphate Vilsmeier-Haack Formylation; Cooling with iceMicrowave irradiation;
参考文献
Jain, Kishor S.; Khedkar, Vijay M.; Arya, Nikhilesh; Rane, Prasad V.; Chaskar, Pratip K.; Coutinho, Evans C.
European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 166 - 175
反应条件
1: 43 percent / 12 h / Heating 2: 76 percent / POCl3, N,N-dimethylaniline / 14 h / Heating View Scheme
参考文献
Baumgartner; Pech; Bohm
Pharmazie, 1993 , vol. 48, # 3 p. 192 - 194
反应条件
acetic acid T=150°C; 40 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/42537 A1, 2005 ;
Location in patent: Page/Page column 57 ;
WO 2005/042537 A1
参考文献
Hoffmann-La Roche Inc.
Patent: US4061656 A1, 1977 ;
参考文献
Hafez; El-Gazzar
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5222 - 5227
