2-氨基-5-苯基噻吩-3-甲酸乙酯合成路线 （共 12 条）
反应条件
morpholine; sulfur in ethanol T=70°C; Gewald reaction; 0.333333 h; Microwave irradiation;
参考文献
Revelant, Germain; Dunand, Sandrine; Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2011 , # 18 art. no. Z45811SS, p. 2935 - 2940
反应条件
1: sulfuric acid / 3 h / Reflux 2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 °C 3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / 80 °C 4: morpholine; sulfur / ethanol / 0.33 h / 70 °C / Microwave irradiation View Scheme
参考文献
Revelant, Germain; Dunand, Sandrine; Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2011 , # 18 art. no. Z45811SS, p. 2935 - 2940
反应条件
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / 80 °C 2: morpholine; sulfur / ethanol / 0.33 h / 70 °C / Microwave irradiation View Scheme
参考文献
Revelant, Germain; Dunand, Sandrine; Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2011 , # 18 art. no. Z45811SS, p. 2935 - 2940
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 °C 2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / 80 °C 3: morpholine; sulfur / ethanol / 0.33 h / 70 °C / Microwave irradiation View Scheme
参考文献
Revelant, Germain; Dunand, Sandrine; Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2011 , # 18 art. no. Z45811SS, p. 2935 - 2940
反应条件
thionyl chloride T=0°C; 24 h; Reflux;
参考文献
Hinsberger, Stefan; De Jong, Johannes C.; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 343 - 351
反应条件
1: 100 percent / 2.5 h / 190 °C 2: 85 percent / POCl3; DMF / 1,2-dichloro-ethane / 1 h / 65 °C View Scheme
参考文献
Organic Letters, , vol. 6, # 12 p. 1991 - 1994
参考文献
Therkelsen, Frans D.; Rottlaender, Mario; Thorup, Niels; Pedersen, Erik Bjerregaard
Organic Letters, 2004 , vol. 6, # 12 p. 1991 - 1994
参考文献
Russo, Filippo; Santagati, Andrea; Santagati, Maria; Caruso, Antonina; Leone, Maria Grazia; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 91 - 96
参考文献
Russo, Filippo; Santagati, Andrea; Santagati, Maria; Caruso, Antonina; Leone, Maria Grazia; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 91 - 96
参考文献
Russo; Santagati; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 2 p. 119 - 122
