2-氨基-5-苯基-噻吩-3-羧酸胺合成路线 （共 7 条）
反应条件
morpholine; sulfur in ethanol T=70°C; Gewald reaction; 0.333333 h; Microwave irradiation;
参考文献
Revelant, Germain; Dunand, Sandrine; Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2011 , # 18 art. no. Z45811SS, p. 2935 - 2940
反应条件
1: sulfuric acid / 3 h / Reflux 2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 °C 3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / 80 °C 4: morpholine; sulfur / ethanol / 0.33 h / 70 °C / Microwave irradiation View Scheme
参考文献
Revelant, Germain; Dunand, Sandrine; Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2011 , # 18 art. no. Z45811SS, p. 2935 - 2940
反应条件
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / 80 °C 2: morpholine; sulfur / ethanol / 0.33 h / 70 °C / Microwave irradiation View Scheme
参考文献
Revelant, Germain; Dunand, Sandrine; Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2011 , # 18 art. no. Z45811SS, p. 2935 - 2940
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 °C 2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / 80 °C 3: morpholine; sulfur / ethanol / 0.33 h / 70 °C / Microwave irradiation View Scheme
参考文献
Revelant, Germain; Dunand, Sandrine; Hesse, Stephanie; Kirsch, Gilbert
Synthesis, 2011 , # 18 art. no. Z45811SS, p. 2935 - 2940
反应条件
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran 2: N-iodo-succinimide / dichloromethane 3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethylene glycol dimethyl ether; water / 100 °C 4: palladium on activated charcoal; hydrogen / ethanol / 80 °C View Scheme
参考文献
Haidle, Andrew M.; Zabierek, Anna A.; Childers, Kaleen K.; Rosenstein, Craig; Mathur, Anjili; Altman, Michael D.; Chan, Grace; Xu, Lin; Bachman, Eric; Mo, Jan-Rung; Bouthillette, Melaney; Rush, Thomas; Tempest, Paul; Marshall, C. Gary; Young, Jonathan R.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1968 - 1973
反应条件
1: N-iodo-succinimide / dichloromethane 2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethylene glycol dimethyl ether; water / 100 °C 3: palladium on activated charcoal; hydrogen / ethanol / 80 °C View Scheme
参考文献
Haidle, Andrew M.; Zabierek, Anna A.; Childers, Kaleen K.; Rosenstein, Craig; Mathur, Anjili; Altman, Michael D.; Chan, Grace; Xu, Lin; Bachman, Eric; Mo, Jan-Rung; Bouthillette, Melaney; Rush, Thomas; Tempest, Paul; Marshall, C. Gary; Young, Jonathan R.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1968 - 1973
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethylene glycol dimethyl ether; water / 100 °C 2: palladium on activated charcoal; hydrogen / ethanol / 80 °C View Scheme
参考文献
Haidle, Andrew M.; Zabierek, Anna A.; Childers, Kaleen K.; Rosenstein, Craig; Mathur, Anjili; Altman, Michael D.; Chan, Grace; Xu, Lin; Bachman, Eric; Mo, Jan-Rung; Bouthillette, Melaney; Rush, Thomas; Tempest, Paul; Marshall, C. Gary; Young, Jonathan R.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1968 - 1973
