2-氨基-4-苯基噻吩-3-羧酸乙酯合成路线 （共 25 条）
反应条件
1: With titanium tetrachloride in dichloromethane T=0°C; 0.5 h; 2: With pyridine in dichloromethane T=0 - 20°C; 3: With sulfur; diethylamine in tetrahydrofuran T=20°C; 2 h;
参考文献
Aurelio, Luigi; Valant, Celine; Flynn, Bernard L.; Sexton, Patrick M.; White, Jonathan M.; Christopoulos, Arthur; Scammells, Peter J.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 18 p. 6550 - 6559
反应条件
sulfur; diethylamine in ethanol 1.5 h;
参考文献
Perrissin; Duc; Narcisse; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 6 p. 563 - 565
反应条件
hydrogen sulfide in ethanol; ethyl acetate; Petroleum ether
参考文献
Moorman, Allan R.; Romagnoli, Romeo; Baraldi, Pier Giovanni
Patent: US2003/73733 A1, 2003 ;
US 20030073733 A1
反应条件
sulfur; diethylamine in ethanol 0.0333333 h;
参考文献
Kathiravan; Shishoo; Chitre; Mahadik; Jain
Synthetic Communications, 2007 , vol. 37, # 23 p. 4273 - 4279
反应条件
1: 59 percent / acetic acid, ammonium acetate / benzene / Heating 2: 76 percent / sulphur, diethylamine / ethanol / 1.5 h View Scheme
参考文献
XENTION LIMITED; JOHN, Derek Edward; FORD, John
Patent: WO2012/131379 A1, 2012 ;
WO 2012/131379 A1
反应条件
1: 59 percent / acetic acid, ammonium acetate / benzene / Heating 2: 76 percent / sulphur, diethylamine / ethanol / 1.5 h View Scheme
参考文献
XENTION LIMITED; JOHN, Derek Edward; FORD, John
Patent: WO2012/131379 A1, 2012 ;
WO 2012/131379 A1
参考文献
Hozien; Atta; Hassan; Abdel-Wahab; Ahmed
Synthetic Communications, 1996 , vol. 26, # 20 p. 3733 - 3755
反应条件
in ethanol 18 h; Heating / reflux;
参考文献
WO2004/111057 A1, ;
Page 30 ;
WO 2004/111057 A1
反应条件
hydrogenchloride in 1,4-dioxane 5 h;
参考文献
Shishoo, C. J.; Devani, M. B.; Karvekar, M. D.; Ullas, G. V.; Ananthan, S.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. <B> 21, # 7 p. 666 - 668
参考文献
Ried,W.; Giesse,R.
Justus Liebigs Annalen der Chemie, 1968 , vol. 713, p. 143 - 148
