2-氨基-4-甲基-5-苯基噻吩-3-羧酸乙酯合成路线 （共 6 条）
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in methanol
5 h; Ambient temperature;
参考文献
Cho, Nobuo; Nara, Yoshi; Harada, Mioko; Sugo, Tsukasa; Masuda, Yasushi; Abe, Akemi; Kusumoto, Keiji; Itoh, Yasuaki; Ohtaki, Tetsuya; Watanabe, Toshifumi; Furuya, Shuichi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1724 - 1737
反应条件
ammonium acetate; hydrogen sulfide; acetic acid
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5744479 A1, 1998 ;
US 5744479 A
反应条件
sulfur in ethanol
T=50°C;
参考文献
Briel; Rybak; Kronbach; Unverferth
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 69 - 77
反应条件
1: NH4OAc, AcOH / benzene / 24 h / Heating
2: S, Et2NH / ethanol / 2 h / 60 °C
3: 96 percent / sodium acetate, H2 / 10 percent Pd/C / methanol / 5 h / Ambient temperature
View Scheme
参考文献
Cho, Nobuo; Nara, Yoshi; Harada, Mioko; Sugo, Tsukasa; Masuda, Yasushi; Abe, Akemi; Kusumoto, Keiji; Itoh, Yasuaki; Ohtaki, Tetsuya; Watanabe, Toshifumi; Furuya, Shuichi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1724 - 1737
反应条件
1: NH4OAc, AcOH / benzene / 24 h / Heating
2: S, Et2NH / ethanol / 2 h / 60 °C
3: 96 percent / sodium acetate, H2 / 10 percent Pd/C / methanol / 5 h / Ambient temperature
View Scheme
参考文献
Cho, Nobuo; Nara, Yoshi; Harada, Mioko; Sugo, Tsukasa; Masuda, Yasushi; Abe, Akemi; Kusumoto, Keiji; Itoh, Yasuaki; Ohtaki, Tetsuya; Watanabe, Toshifumi; Furuya, Shuichi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1724 - 1737
参考文献
Fukuoka, Koichiro; Yamamoto, Hiroaki; Kimura, Kazuhiro; Kawakami, Junichi; Miki, Shokyo
Patent: US2003/55269 A1, 2003 ;
