N-(2'-氰基联苯-4-基甲基)-L-缬氨酸甲酯盐酸盐合成路线 （共 3 条）
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=25 - 30°C; 12 h; 2: With hydrogenchloride in water; toluene T=20 - 30°C; 2 h;
参考文献
WO2012/56294 A1, ;
Page/Page column 14 ;
反应条件
sodium hydrogencarbonate in water; xylene T=25 - 30°C; 0.5 h;
参考文献
SATYANARAYANA REDDY, Manne; KISHORE KUMAR, Muppa; RAMA SUBBA REDDY, Karamala
Patent: WO2008/7391 A2, 2008 ;
Location in patent: Page/Page column 16 ;
反应条件
1.1: sodium hydrogencarbonate / dichloromethane; water 1.2: 1 h / 0 - 5 °C 2.1: sodium azide; tributyltin chloride / o-xylene / 24 h / 135 - 138 °C 3.1: sodium hydroxide; water / o-xylene / 10 - 60 °C 3.2: 15 - 20 °C / pH 2.5 - 3 View Scheme
参考文献
JUBILANT LIFE SCIENCES LTD.; KHANNA, Jag, Mohan; HOLKAR, Anil, Ganpatrao; ALLUGULASETTY, Radheshyam; YELAKANTI, Chandrashekhar
Patent: WO2012/56294 A1, 2012 ;
