2-氯-5,7-二甲基-3-喹啉甲醛合成路线 （共 5 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
2 h; Inert atmosphereReflux;
2: N-Acetyl-3,5-dimethylaniline T=20°C; Vilsmeier-Haack reaction; 3 h; Inert atmosphere;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan S.; PHUAN, Puay-Wah; KURTH, Mark J.; KNAPP, John
Patent: WO2012/166654 A1, 2012 ;
Location in patent: Page/Page column 87 ;
WO 2012/166654 A1
反应条件
1.1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: pH 12 - 14 / Cooling with ice
2.1: trichlorophosphate / 2 h / Inert atmosphere; Reflux
2.2: 3 h / 20 °C
2.3: Cooling with ice
View Scheme
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan S.; PHUAN, Puay-Wah; KURTH, Mark J.; KNAPP, John
Patent: WO2012/166654 A1, 2012 ;
WO 2012/166654 A1
反应条件
1: With hydroxylamine hydrochloride; triethylamine in ethanol
3 h; Reflux;
2: With hydrogenchloride in water
3: With thionyl chloride in benzene
4 h; Inert atmosphereReflux;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan S.; PHUAN, Puay-Wah; KURTH, Mark J.; KNAPP, John
Patent: WO2012/166654 A1, 2012 ;
Location in patent: Page/Page column 87 ;
WO 2012/166654 A1
反应条件
1: hydroxylamine hydrochloride; triethylamine / ethanol / 3 h / Reflux
2: thionyl chloride / benzene / 4 h / Inert atmosphere; Reflux
3: 1,4-dioxane / Reflux
View Scheme
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan S.; PHUAN, Puay-Wah; KURTH, Mark J.; KNAPP, John
Patent: WO2012/166654 A1, 2012 ;
WO 2012/166654 A1
反应条件
1.1: hydroxylamine hydrochloride; triethylamine / ethanol / 3 h / Reflux
1.3: 4 h / Inert atmosphere; Reflux
2.1: 1,4-dioxane / Reflux
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C
View Scheme
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; VERKMAN, Alan S.; PHUAN, Puay-Wah; KURTH, Mark J.; KNAPP, John
Patent: WO2012/166654 A1, 2012 ;
WO 2012/166654 A1
