N-苯甲酰-2'-脱氧胞苷合成路线 （共 36 条）
反应条件
pyridine; sodium hydroxide; triethylamine 1.) RT, 1 h, 2.) MeOH, THF, 0 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Ohtsuka; Ono; Ikehara
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 11 p. 3274 - 3280
反应条件
Robins's deoxygenation; Yield given. Multistep reaction;
参考文献
Voss, James J. De; Hangeland, Jon J.; Townsend, Craig A.
Journal of Organic Chemistry, 1994 , vol. 59, # 10 p. 2715 - 2723
反应条件
1: 72 percent / pyridine / 70 h / Ambient temperature 2: 87 percent / pyridine / 1.5 h / Ambient temperature 3: 63 percent / LiI / ethyl acetate / 2.5 h / Heating 4: 94 percent / triethylamine / Pd/C / 1,2-dimethoxy-ethane / 1.25 h / 1810.02 Torr 5: 90 percent / HCl-EtOH / ethyl acetate / 0.5 h / 10 - 15 °C 6: 75 percent / ammonia / methanol / 22 h / Ambient temperature; pH 12 View Scheme
参考文献
Kaskar; Markovac
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 6 p. 1531 - 1533
反应条件
pyridine 1 h; Ambient temperature;
参考文献
Charubala, R.; Uhlmann, E.; Beiter, A. H.; Pfleiderer, W.
Synthesis, 1984 , # 11 p. 965 - 968
反应条件
1: in pyridine T=20°C; 6 h; 2: With sodium hydrogencarbonate in water; ethyl acetate 2 h;
参考文献
Mitsui Chemicals, Inc.
Patent: US2003/229223 A1, 2003 ;
Location in patent: Page 4 ;
反应条件
ethylenediamine T=40°C; 20 h;
参考文献
Barnett, Richard W.; Letsinger, Robert L.
Tetrahedron Letters, 1981 , vol. 22, p. 991 - 994
反应条件
ammonia; methylamine in water T=65°C; 1 h; deprotection reagent; Product distribution;
参考文献
Reddy, M. P.; Hanna, N. B.; Farooqui, Firdous
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4311 - 4314
反应条件
1: pyridine; 4-(N,N-dimethlyamino)pyridine; triethylamine / 4 h / 20 °C 2: pyridine / dichloromethane / 0.08 h / 20 °C / Large scale reaction View Scheme
参考文献
Janczyk, Matthaeus; Appel, Bettina; Springstubbe, Danilo; Fritz, Hans-Joachim; Mueller, Sabine
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 8 p. 1510 - 1513
反应条件
1: 72 percent / pyridine / 70 h / Ambient temperature 2: 87 percent / pyridine / 1.5 h / Ambient temperature 3: 63 percent / LiI / ethyl acetate / 2.5 h / Heating 4: 94 percent / triethylamine / Pd/C / 1,2-dimethoxy-ethane / 1.25 h / 1810.02 Torr 5: 90 percent / HCl-EtOH / ethyl acetate / 0.5 h / 10 - 15 °C View Scheme
参考文献
Kaskar; Markovac
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 6 p. 1531 - 1533
反应条件
1: in pyridine
T=20°C; 6 h;
2: With sodium hydrogencarbonate in water; ethyl acetate
2 h;
参考文献
Mitsui Chemicals, Inc.
Patent: US2003/229223 A1, 2003 ;
Location in patent: Page 4 ;
