4-甲氧基吲哚-3-乙腈合成路线 （共 11 条）
反应条件
sodium hydroxide; formaldehyd; tetrabutyl ammonium fluoride; acetic acid; dimethyl amine in tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene
参考文献
Centre National de la Recherche Scientifique
Patent: EP2266562 A1, 2010 ;
反应条件
sodium tetrahydroborate in methanol; formamide T=100°C; 5 h;
参考文献
Yamada, Fumio; Hashizume, Tomoko; Somei, Masanori
Heterocycles, 1998 , vol. 47, # 1 p. 509 - 516
反应条件
magnesium; methyl iodide in diethyl ether T=20°C; 1 h;
参考文献
Pedras; Chumala; Suchy
Phytochemistry, 2003 , vol. 64, # 5 p. 949 - 956
反应条件
carbon disulfide; triethylamine in acetonitrile T=40°C; 20 h;
参考文献
Pedras, M. Soledade C.; Yaya, Estifanos E.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1149 - 1166
反应条件
1: 57 percent / NaBH4, dimethylamine / H2O / 2 h / Ambient temperature 2: 86 percent / dimethylformamide; H2O / 1 h / Heating View Scheme
参考文献
Pedras, M. Soledade C.; Yaya, Estifanos E.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1149 - 1166
反应条件
in water; N,N-dimethyl-formamide 1 h; Heating;
参考文献
Yamada, Fumio; Kobayashi, Kensuke; Shimizu, Aya; Aoki, Naokatsu; Somei, Masanori
Heterocycles, 1993 , vol. 36, # 12 p. 2783 - 2804
反应条件
1.1: trichlorophosphate / 0 - 20 °C 2.1: Tl(OCOCF3)3; trifluoroacetic acid / 3 h / 30 °C 2.2: 1 h / 25 °C 2.3: 1 h / 110 °C 3.1: ammonium acetate / 1.5 h / 105 °C 4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C 5.1: triethylamine; carbon disulfide / acetonitrile / 20 h / 40 °C View Scheme
参考文献
Pedras, M. Soledade C.; Yaya, Estifanos E.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1149 - 1166
反应条件
1.1: Tl(OCOCF3)3; trifluoroacetic acid / 3 h / 30 °C 1.2: 1 h / 25 °C 1.3: 1 h / 110 °C 2.1: ammonium acetate / 1.5 h / 105 °C 3.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C 4.1: triethylamine; carbon disulfide / acetonitrile / 20 h / 40 °C View Scheme
参考文献
Pedras, M. Soledade C.; Yaya, Estifanos E.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1149 - 1166
反应条件
1: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C 2: triethylamine; carbon disulfide / acetonitrile / 20 h / 40 °C View Scheme
参考文献
Pedras, M. Soledade C.; Yaya, Estifanos E.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1149 - 1166
反应条件
in water T=80°C; 2 h; Yield given;
参考文献
Arbain, Dayar; Sargent, Melvyn V.
Australian Journal of Chemistry, 1987 , vol. 40, # 9 p. 1527 - 1536
