4-甲氧基-7,8-二氢[1,3]二氧杂环戊并[4,5-g]异喹啉合成路线 (共 10 条)
参考文献
Fleischhacker, Wilhelm; Richter, Bernd; Urban, Ernst
Monatshefte fuer Chemie, 1989 , vol. 120, p. 765 - 770
反应条件
sodium hydroxide; trichlorophosphate in dichloromethane; water; toluene
参考文献
Mitsubishi Chemical Industries Limited
Patent: US4746747 A1, 1988 ;
反应条件
potassium permanganate in tetrahydrofuran
0.416667 h;
参考文献
Fleischhacker, Wilhelm; Richter, Bernd; Urban, Ernst
Monatshefte fuer Chemie, 1989 , vol. 120, p. 765 - 770
反应条件
1: 71 percent / K2CO3 / dimethylformamide / 1.5 h / 100 °C
2: 1.) Mg / 1.) THF, 40 deg C, 40 min, 2.) RT, overnight
3: 87 percent / pyridine, SOCl2 / toluene / 3 h / 60 °C
4: 46 percent / POCl3 / 7 h / 100 °C
5: 60 percent / ethanol. NH3 / 10 h / 110 °C
View Scheme
参考文献
Shirasaka, Tadashi; Takuma, Yuki; Imaki, Naoshi
Synthetic Communications, 1990 , vol. 20, # 8 p. 1223 - 1232
反应条件
1: 87 percent / pyridine, SOCl2 / toluene / 3 h / 60 °C
2: 46 percent / POCl3 / 7 h / 100 °C
3: 60 percent / ethanol. NH3 / 10 h / 110 °C
View Scheme
参考文献
Shirasaka, Tadashi; Takuma, Yuki; Imaki, Naoshi
Synthetic Communications, 1990 , vol. 20, # 8 p. 1223 - 1232
反应条件
potassium cyanide; potassium hydroxide in butan-1-ol
参考文献
Korbonits,D.; Harsanyi,K.
Chemische Berichte, 1966 , vol. 99, p. 273 - 280
反应条件
1: TFA, NaBH4 / CH2Cl2 / Ambient temperature
2: 63 percent / NaOMe, I2 / methanol / 0.5 h
View Scheme
参考文献
Simig, Gy.; Schlosser, M.
ACH - Models in Chemistry, 1994 , vol. 131, # 2 p. 217 - 228
反应条件
potassium hydroxide; ammonia
参考文献
Beke et al.
Acta Chimica Academiae Scientiarum Hungaricae, 1958 , vol. 16, p. 439,442
Acta Chimica Academiae Scientiarum Hungaricae, 1959 , vol. 19, p. 267,270
参考文献
Decker; Becker
Justus Liebigs Annalen der Chemie, 1913 , vol. 395, p. 335
Chem. Zentralbl., 1914 , vol. 85, # I p. 89
Full Text Show Details
Decker
Patent: DE245095 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 10, p. 1187
反应条件
methanol; sodium tetrahydroborate
T=0 - 20°C; 18 h;
参考文献
PAIN THERAPEUTICS, INC.
Patent: WO2010/51374 A1, 2010 ;
Location in patent: Page/Page column 127 ;