1,5-二甲基-6H-吡啶并[4,3-b]咔唑合成路线 （共 33 条）
反应条件
ammonium formate; tetrakis(triphenylphosphine) palladium(0) in methanol
Heating;
参考文献
Miki, Yasuyoshi; Tsuzaki, Yasuhiko; Hibino, Hajime; Aoki, Yoshiyuki
Synlett, 2004 , # 12 p. 2206 - 2208
反应条件
ammonia; sodium in ammonia
参考文献
Hogan, Iain; Jenkins, Paul; Sainsbury, Malcolm
Tetrahedron Letters, 1988 , vol. 29, # 49 p. 6505 - 6508
反应条件
palladium on activated charcoal in decalin
1.5 h; Heating;
参考文献
Baeckvall, Jan-E.; Plobeck, Niklas A.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4528 - 4531
反应条件
trichlorophosphate; palladium on activated charcoal
Yield given. Multistep reaction;
参考文献
Naito, Takeaki; Iida, Naoko; Ninomiya, Ichiya
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 99 - 104
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Narasimhan; Gokhale
Journal of the Chemical Society - Series Chemical Communications, 1985 , vol. NO. 2, p. 86 - 87
反应条件
1: triethylamine / CHCl3
2: 1.) phosphorus trichloride oxide / 2.) 10percent palladium charcoal
View Scheme
参考文献
Naito, Takeaki; Iida, Naoko; Ninomiya, Ichiya
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 99 - 104
反应条件
1: in tetrahydrofuran
T=0 - 20°C; 6.5 h;
2: With AlCl3, aluminium chloride; sodium tetrahydroborate in tetrahydrofuran
T=20°C; 3 h;
参考文献
Ramkumar, Nagarajan; Nagarajan, Rajagopal
Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 736 - 741
反应条件
1: NaBH4, CoCl2 / methanol / 0.5 h / 0 °C
2: pyridine / 1 h / Ambient temperature
3: 94 mg / POCl3 / toluene / 1 h / Heating
4: 82 percent / 10percent palladium on carbon / decahydronaphthalene / 1.5 h / Heating
View Scheme
参考文献
Baeckvall, Jan-E.; Plobeck, Niklas A.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4528 - 4531
反应条件
1: 57 percent / chloranil / xylene / 2 h / Heating
2: NaBH4, CoCl2 / methanol / 0.5 h / 0 °C
3: pyridine / 1 h / Ambient temperature
4: 94 mg / POCl3 / toluene / 1 h / Heating
5: 82 percent / 10percent palladium on carbon / decahydronaphthalene / 1.5 h / Heating
View Scheme
参考文献
Baeckvall, Jan-E.; Plobeck, Niklas A.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4528 - 4531
反应条件
1: 1) lithium diisopropylamide / 1) THF, -78 deg C, 1 h, 2) -78 deg C, 30 min
2: 90 percent / Na(Hg), Na2HPO4 / methanol; tetrahydrofuran / 4 h / 25 °C
3: 57 percent / chloranil / xylene / 2 h / Heating
4: NaBH4, CoCl2 / methanol / 0.5 h / 0 °C
5: pyridine / 1 h / Ambient temperature
6: 94 mg / POCl3 / toluene / 1 h / Heating
7: 82 percent / 10percent palladium on carbon / decahydronaphthalene / 1.5 h / Heating
View Scheme
参考文献
Baeckvall, Jan-E.; Plobeck, Niklas A.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4528 - 4531
