反应条件
1: methyl 2-(2-(6-chloropyrimidin-4-oxy)phenyl)acetate; trimethyl orthoformate With titanium tetrachloride; triethylamine in dichloromethane T=-5 - 20°C; Inert atmosphere; 2: dimethyl sulfate With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide in water; toluene T=20 - 50°C;
参考文献
Liu, Shangzhong; Mu, Canxian; Wang, Wenjun; Chen, Jianwei; Wang, Shuguang
Patent: US2010/179320 A1, 2010 ;
Location in patent: Page/Page column 3 ;