CIS-4-环己烯-1,2-二甲酸二甲酯合成路线 （共 22 条）
反应条件
hydrazine hydrate in methanol 12 h; Reflux;
参考文献
Ekmekci, Zeynep; Balci, Metin
European Journal of Organic Chemistry, 2012 , # 26 p. 4988 - 4995
反应条件
sodium hydroxide; disodium hydrogenphosphate; potassium dihydrogenphosphate; pig liver esterase T=25°C; 216 h;
参考文献
Kriesel, Josh; Karpishin, Timothy B.; Bivin, Donald B.; Merrill, Grant; Stuart Edelstein, Martin; Smith, Thomas H.; Whiteford, Jeffery A.; Jonas, Robert Thomas
Patent: US2003/199688 A1, 2003 ;
Location in patent: Page/Page column 29 ;
反应条件
T=30°C; 3 h; pig liver esterase (PLE), pH 8.0 phosphate buffer-10 percent acetone; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Goswami, Animesh; Kissick, Thomas P.
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 483 - 488
反应条件
1: Na / ethanol / 0.5 h / Heating 2: 2percent H2SO4 3: 79 percent / acetic anhydride / 60 - 70 °C View Scheme
参考文献
Nasarow; Kutscherow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1954 , p. 329,333; engl. Ausg. S. 269, 272
反应条件
1: 96 percent / (NH4)2SO4, phosphate buffer / 96 h / Ambient temperature; pig-liver esterase, pH 7.0 2: 1.) K(t-BuO); 2.) concd. H2SO4 / 1.) THF, r.t., 1 h; 2.) reflux, 8 h 3: H2 / 10percent Pd/C / ethyl acetate / 24 h View Scheme
参考文献
Ito, Yoshio N.; Ariza, Xavier; Beck, Albert K.; Bohac, Andrej; Ganter, Camille; et al.
Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2071 - 2110
反应条件
sodium hydroxide; disodium hydrogenphosphate; potassium dihydrogenphosphate; pig liver esterase T=25°C; 216 h;
参考文献
Kriesel, Josh; Karpishin, Timothy B.; Bivin, Donald B.; Merrill, Grant; Stuart Edelstein, Martin; Smith, Thomas H.; Whiteford, Jeffery A.; Jonas, Robert Thomas
Patent: US2003/199688 A1, 2003 ;
Location in patent: Page/Page column 29 ;
反应条件
T=30°C; 3 h; pig liver esterase (PLE), pH 8.0 phosphate buffer-10 percent acetone; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Goswami, Animesh; Kissick, Thomas P.
Organic Process Research and Development, 2009 , vol. 13, # 3 p. 483 - 488
参考文献
Bernath, Gabor; Stajer, Geza; Szabo, Angela E.; Fueloep, Ferenc; Sohar, Pal
Tetrahedron, 1985 , vol. 41, # 7 p. 1353 - 1366
反应条件
ethanol; platinum Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 72, p. 983,985
Org. Synth. Coll. Vol. IV, <1963> 304
反应条件
1: methanol. sodium methylate 2: acetyl chloride 3: palladium; chloroform / Hydrogenation View Scheme
参考文献
Nasarow; Kutscherow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1954 , p. 329,333; engl. Ausg. S. 269, 272
