1-苯基-1,3-丙二醇合成路线 （共 84 条）
反应条件
potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate in tetrahydrofuran; methanol
12 h; Ambient temperature; Yield given;
参考文献
Angelaud, Remy
Tetrahedron Letters, 1995 , vol. 36, # 22 p. 3861 - 3864
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol
参考文献
Yoshida, Kiyoshi; Horikoshi, Yoichiro; Eta, Masaaki; Chikazawa, Jun; Ogishima, Masayuki; Fukuda, Yohichi; Sato, Hiroki
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 2967 - 2972
反应条件
1: Et3N; MgCl2
2: NaBH4 / methanol; tetrahydrofuran / Heating
View Scheme
参考文献
Liang, Yuzeng; Narayanasamy, Janarthanan; Schinazi, Raymond F.; Chu, Chung K.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2178 - 2189
反应条件
1.1: n-BuLi; t-BuOK / tetrahydrofuran; hexane / 0.75 h / -80 °C
1.2: 50 percent / tetrahydrofuran; hexane / 0.08 h / -80 °C
2.1: n-BuLi; t-BuOK / tetrahydrofuran; hexane / 0.75 h / -80 °C
2.2: tetrahydrofuran; hexane / 0.08 h / -80 °C
2.3: 65 percent / aq. H2SO4 / 1 h / 20 °C
3.1: m-CPBA / CH2Cl2 / 2 h / 20 °C
4.1: 70 percent / aq. H2O2; KF; KHCO3 / methanol; tetrahydrofuran / 12 h / 20 °C
View Scheme
参考文献
Angelaud, Remy; Landais, Yannick
Tetrahedron, 2000 , vol. 56, # 14 p. 2025 - 2036
反应条件
1.1: n-BuLi; t-BuOK / tetrahydrofuran; hexane / 0.75 h / -80 °C
1.2: tetrahydrofuran; hexane / 0.08 h / -80 °C
1.3: 65 percent / aq. H2SO4 / 1 h / 20 °C
2.1: m-CPBA / CH2Cl2 / 2 h / 20 °C
3.1: 70 percent / aq. H2O2; KF; KHCO3 / methanol; tetrahydrofuran / 12 h / 20 °C
View Scheme
参考文献
Angelaud, Remy; Landais, Yannick
Tetrahedron, 2000 , vol. 56, # 14 p. 2025 - 2036
反应条件
1: m-CPBA / CH2Cl2 / 2 h / 20 °C
2: 70 percent / aq. H2O2; KF; KHCO3 / methanol; tetrahydrofuran / 12 h / 20 °C
View Scheme
参考文献
Angelaud, Remy; Landais, Yannick
Tetrahedron, 2000 , vol. 56, # 14 p. 2025 - 2036
反应条件
2: 2.) 30percent H2O2, NaHCO3 / 1.) H2PtCl6*6H2O
View Scheme
参考文献
Tamao, Kohei; Tanaka, Tetsu; Nakajima, Takashi; Sumiya, Ritsuo; Arai, Hitoshi; Ito, Yoshihiko
Tetrahedron Letters, 1986 , vol. 27, # 29 p. 3377 - 3380
反应条件
zeolite (H-ZSM 5); sodium cyanoborohydride in 1,2-dichloro-ethane
6 h; Heating; Yield givenYields of byproduct given;
参考文献
Gupta; Vankar
Tetrahedron Letters, 1999 , vol. 40, # 7 p. 1369 - 1372
反应条件
water; hydrogen; nickel
参考文献
Rupe; Mueller
Helvetica Chimica Acta, 1921 , vol. 4, p. 847
反应条件
1: 57 percent / H2SO4 conc. / H2O / 7 h / Heating
2: 83 percent / aq. HCl / 20 h / 80 °C
3: 54 percent / KOH / diethyl ether; methanol / 3 h
View Scheme
参考文献
Merkley, Nadine; Warkentin, John
Canadian Journal of Chemistry, 2002 , vol. 80, # 9 p. 1187 - 1195
