3-氨基-5,6-二氯-吡嗪-2-羧酸合成路线 （共 2 条）
反应条件
1: With sodium hydroxide; water
0.25 h; Heating / reflux;
2: With hydrogenchloride in water
T=20°C;
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2006/88920 A1, 2006 ;
Location in patent: Page/Page column 147 ;
WO 2006/088920 A1
反应条件
1: With sulfuric acid; nitric acid
T=0 - 20°C; 3 h;
2: With sodium carbonate in water; ethyl acetate
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2006/88920 A1, 2006 ;
Location in patent: Page/Page column 147 ;
WO 2006/088920 A1
