1: sodium hydroxide / 2 h / 20 °C
2: neat (no solvent) / 1 h / 125 °C
3: hydrogen bromide / water / 24 h / 70 °C
4: triethylamine / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Hofer, Sandra; Kratschmar, Denise V.; Schernthanner, Brigitte; Vuorinen, Anna; Schuster, Daniela; Odermatt, Alex; Easmon, Johnny
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5397 - 5400
1: sodium hydroxide / 2 h / 20 °C
2: neat (no solvent) / 1 h / 125 °C
3: hydrogen bromide / water / 24 h / 70 °C
4: triethylamine / dichloromethane / 0 - 20 °C
View Scheme
参考文献
Hofer, Sandra; Kratschmar, Denise V.; Schernthanner, Brigitte; Vuorinen, Anna; Schuster, Daniela; Odermatt, Alex; Easmon, Johnny
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 19 p. 5397 - 5400
1: 2-Chloro-1H-1,3-benzimidazole With sodium hydride in N,N-dimethyl-formamide
2: 1-(chloromethyl)-4-(trifluoromethyl)benzene in N,N-dimethyl-formamide
T=20°C; Further stages.;
参考文献
Da Settimo; Boldrini; Primofiore; La Motta; Taliani; Simorini; Novellino; Greco; Lavecchia
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4359 - 4369
1,8-diazabicyclo[5.4.0]undec-7-ene in ethanol; hexane; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US5814646 A1, 1998 ;
US 5814646 A
Title/Abstract Full Text Show Details
Eli Lilly and Company
Patent: US5624937 A1, 1997 ;
US 5624937 A
