1.1: sodium iodide / acetone / |Reflux 2.1: potassium carbonate / acetonitrile 3.1: sodium tetrahydroborate / methanol / 2 h / 0 - 5 °C / |Inert atmosphere 4.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / 20 °C / |Inert atmosphere 5.1: Amano Lipase PS / toluene / 24 h 5.2: 24 h / 20 °C 6.1: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C View Scheme

1.1: potassium carbonate / acetonitrile 2.1: sodium tetrahydroborate / methanol / 2 h / 0 - 5 °C / |Inert atmosphere 3.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / 20 °C / |Inert atmosphere 4.1: Amano Lipase PS / toluene / 24 h 4.2: 24 h / 20 °C 5.1: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C View Scheme

1.1: sodium tetrahydroborate / methanol / 2 h / 0 - 5 °C / |Inert atmosphere 2.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / 20 °C / |Inert atmosphere 3.1: Amano Lipase PS / toluene / 24 h 3.2: 24 h / 20 °C 4.1: sodium hydroxide; water / methanol / 1 h / 0 - 20 °C View Scheme

sodium tetrahydroborate in ethanol; water 3 h; Heating;

1: hydrogenchloride; water / chloroform / 2 h / 60 °C 2: aluminum trihydride / tetrahydrofuran / 0 - 20 °C View Scheme

1.1: (S)-[α,α-bis(3,5-bistrifluoromethyl)phenyl]-2-pyrrolidine methanol trimethylsilyl ether; benzoic acid / chloroform / 22 h / -50 °C / Inert atmosphere 2.1: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / methanol; water; acetonitrile / 3 h / 0 - 20 °C / Inert atmosphere 3.1: methanol / diethyl ether; toluene / 3 h / 0 - 20 °C / Inert atmosphere 4.1: lithium diisopropyl amide / diethyl ether / 1 h / -100 °C / Inert atmosphere 4.2: 1 h / -100 °C / Inert atmosphere 5.1: dimethylsulfide borane complex / hexane / 0 °C / Inert atmosphere 5.2: 1 h / Inert atmosphere; Reflux 6.1: triethylamine / dichloromethane / 2 h / Inert atmosphere 7.1: 1.5 h / 20 °C / Inert atmosphere 8.1: sodium hydroxide / dichloromethane; water / Inert atmosphere 9.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3 h / Inert atmosphere; Reflux View Scheme

1: triethylamine / dichloromethane / 2 h / Inert atmosphere 2: 1.5 h / 20 °C / Inert atmosphere 3: sodium hydroxide / dichloromethane; water / Inert atmosphere 4: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3 h / Inert atmosphere; Reflux View Scheme

1.1: lithium diisopropyl amide / diethyl ether / 1 h / -100 °C / Inert atmosphere 1.2: 1 h / -100 °C / Inert atmosphere 2.1: dimethylsulfide borane complex / hexane / 0 °C / Inert atmosphere 2.2: 1 h / Inert atmosphere; Reflux 3.1: triethylamine / dichloromethane / 2 h / Inert atmosphere 4.1: 1.5 h / 20 °C / Inert atmosphere 5.1: sodium hydroxide / dichloromethane; water / Inert atmosphere 6.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3 h / Inert atmosphere; Reflux View Scheme

1.1: methanol / diethyl ether; toluene / 3 h / 0 - 20 °C / Inert atmosphere 2.1: lithium diisopropyl amide / diethyl ether / 1 h / -100 °C / Inert atmosphere 2.2: 1 h / -100 °C / Inert atmosphere 3.1: dimethylsulfide borane complex / hexane / 0 °C / Inert atmosphere 3.2: 1 h / Inert atmosphere; Reflux 4.1: triethylamine / dichloromethane / 2 h / Inert atmosphere 5.1: 1.5 h / 20 °C / Inert atmosphere 6.1: sodium hydroxide / dichloromethane; water / Inert atmosphere 7.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3 h / Inert atmosphere; Reflux View Scheme

1.1: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / methanol; water; acetonitrile / 3 h / 0 - 20 °C / Inert atmosphere 2.1: methanol / diethyl ether; toluene / 3 h / 0 - 20 °C / Inert atmosphere 3.1: lithium diisopropyl amide / diethyl ether / 1 h / -100 °C / Inert atmosphere 3.2: 1 h / -100 °C / Inert atmosphere 4.1: dimethylsulfide borane complex / hexane / 0 °C / Inert atmosphere 4.2: 1 h / Inert atmosphere; Reflux 5.1: triethylamine / dichloromethane / 2 h / Inert atmosphere 6.1: 1.5 h / 20 °C / Inert atmosphere 7.1: sodium hydroxide / dichloromethane; water / Inert atmosphere 8.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 3 h / Inert atmosphere; Reflux View Scheme