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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
486455-30-5
合成路线
（共 12 条）
29540-83-8
对苄基三氟甲磺酸
+
214360-76-6
3-羟基苯硼酸频哪酯
→
反应条件
486455-30-5
反应条件
lithium hydroxide; palladium diacetate in tetrahydrofuran; water T=20°C; Suzuki-Miyaura cross-coupling; 4 h;
参考文献
Ishikawa, Shunpei; Manabe, Kei
Chemical Communications, 2006 , # 24 p. 2589 - 2591
591-20-8
间溴苯酚
+
5720-05-8
4-甲基苯硼酸
→
反应条件
486455-30-5
反应条件
tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether Suzuki Coupling; 12 h; Inert atmosphereReflux;
参考文献
GENFIT
Patent: US2010/4159 A1, 2010 ;
Location in patent: Page/Page column 43; 46 ;
6330-12-7
→
反应条件
486455-30-5
反应条件
hydrogen bromide; oxygen; copper(ll) bromide in 1,4-dioxane; water T=20°C; 20 h; Sealed tube;
参考文献
Kikushima, Kotaro; Nishina, Yuta
RSC Advances, 2013 , vol. 3, # 43 p. 20150 - 20156
591-20-8
间溴苯酚
+
29540-83-8
对苄基三氟甲磺酸
→
反应条件
486455-30-5
反应条件
1: 1-bromo-3-hydroxy-benzene With tert.-butyl lithium in diethyl ether; pentane T=-78°C; 0.5 h; 2: With zinc(II) chloride in tetrahydrofuran T=-78 - 20°C; 3: p-trifluoromethanesulfonyloxytoluene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; palladium diacetate in tetrahydrofuran T=20°C; Negishi coupling reaction; 0.333333 h;
参考文献
Shimizu, Haruka; Manabe, Kei
Tetrahedron Letters, 2006 , vol. 47, # 33 p. 5927 - 5931
→
反应条件
486455-30-5
反应条件
potassium fluoride; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; palladium diacetate in tetrahydrofuran; water T=20°C; Suzuki-Miyaura coupling; 6 h;
参考文献
Ishikawa, Shunpei; Manabe, Kei
Chemistry Letters, 2006 , vol. 35, # 2 p. 164 - 165
150-19-6
3-甲氧基苯酚
+
4294-57-9
对甲苯基溴化镁
→
反应条件
486455-30-5
反应条件
NiCl2(phenyldi(cyclohexyl)phosphine)2; phenyldicyclohexylphosphine in various solvent(s) T=90°C; 15 h;
参考文献
Dankwardt, John W.
Angewandte Chemie - International Edition, 2004 , vol. 43, # 18 p. 2428 - 2432
24423-07-2
(7CI,8CI)-m-(对甲苯)-苯甲醚
→
反应条件
486455-30-5
反应条件
hydrogen iodide 2 h; Heating;
参考文献
Mor, Marco; Rivara, Silvia; Lodola, Alessio; Plazzi, Pier Vincenzo; Tarzia, Giorgio; Duranti, Andrea; Tontini, Andrea; Piersanti, Giovanni; Kathuria, Satish; Piomelli, Daniele
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 4998 - 5008
106-38-7
对溴甲苯
→
反应条件
486455-30-5
反应条件
1: 94 percent / aq. Na2CO3; Pd(PPh3)4 / ethanol; toluene / 1 h / Heating 2: 85 percent / aq. HI / 2 h / Heating View Scheme
参考文献
Mor, Marco; Rivara, Silvia; Lodola, Alessio; Plazzi, Pier Vincenzo; Tarzia, Giorgio; Duranti, Andrea; Tontini, Andrea; Piersanti, Giovanni; Kathuria, Satish; Piomelli, Daniele
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 4998 - 5008
10365-98-7
3-甲氧基苯硼酸
→
反应条件
486455-30-5
反应条件
1: 94 percent / aq. Na2CO3; Pd(PPh3)4 / ethanol; toluene / 1 h / Heating 2: 85 percent / aq. HI / 2 h / Heating View Scheme
参考文献
Mor, Marco; Rivara, Silvia; Lodola, Alessio; Plazzi, Pier Vincenzo; Tarzia, Giorgio; Duranti, Andrea; Tontini, Andrea; Piersanti, Giovanni; Kathuria, Satish; Piomelli, Daniele
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 4998 - 5008
591-20-8
间溴苯酚
→
反应条件
486455-30-5
反应条件
1: potassium acetate / isopropyl alcohol / 2 h / 82 °C / |Green chemistry 2: potassium carbonate / isopropyl alcohol; water / 3 h / |Green chemistry View Scheme
参考文献
Pandarus, Valerica; Gingras, Genevieve; Beland, Francois; Ciriminna, Rosaria; Pagliaro, Mario
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 897 - 901
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