1.1: sulfuric acid / methanol / -10 - 0 °C 1.2: 2 h / -10 - 0 °C 1.3: pH 8 - 9 2.1: isopropyl alcohol / 3 h / 25 - 30 °C 3.1: sodium carbonate / water / pH 8 - 9 4.1: water; lithium hydroxide hydrate / tetrahydrofuran / 0 - 30 °C 5.1: water; tetrahydrofuran / 6 h / 25 - 30 °C 5.2: pH 2 View Scheme

1.1: isopropyl alcohol / 3 h / 25 - 30 °C 2.1: sodium carbonate / water / pH 8 - 9 3.1: water; lithium hydroxide hydrate / tetrahydrofuran / 0 - 30 °C 4.1: water; tetrahydrofuran / 6 h / 25 - 30 °C 4.2: pH 2 View Scheme

1.1: sodium carbonate / water / pH 8 - 9 2.1: water; lithium hydroxide hydrate / tetrahydrofuran / 0 - 30 °C 3.1: water; tetrahydrofuran / 6 h / 25 - 30 °C 3.2: pH 2 View Scheme

1.1: palladium 10 on activated carbon; hydrogen / ethanol / 5 h / 25 °C 1.2: pH 5 - 6 2.1: triethylamine / dichloromethane / 10 h / 20 °C View Scheme

1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / |Inert atmosphere 3.1: iso-propylmagnesium bromide / tetrahydrofuran / -20 °C / |Inert atmosphere 3.2: 0.25 h / -5 °C / |Inert atmosphere 3.3: 0.08 h 4.1: acetic acid / dichloromethane / 2 h / 20 °C 5.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C 5.2: pH 2 - 3 View Scheme

1.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C 2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / |Inert atmosphere 3.1: iso-propylmagnesium bromide / tetrahydrofuran / -20 °C / |Inert atmosphere 3.2: 0.25 h / -5 °C / |Inert atmosphere 3.3: 0.08 h 4.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 4560.31 Torr / |Autoclave 5.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C 5.2: pH 2 - 3 View Scheme

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / |Inert atmosphere 2.1: iso-propylmagnesium bromide / tetrahydrofuran / -20 °C / |Inert atmosphere 2.2: 0.25 h / -5 °C / |Inert atmosphere 2.3: 0.08 h 3.1: acetic acid / dichloromethane / 2 h / 20 °C 4.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C 4.2: pH 2 - 3 View Scheme

1.1: sodium hydroxide / water; acetonitrile / 12 h / 0 - 45 °C 1.2: pH 6 2.1: sodium tetrahydroborate; iodine; methanol / tetrahydrofuran / 2 h / 0 - 5 °C / |Reflux 3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C 4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -10 °C / |Inert atmosphere 5.1: iso-propylmagnesium bromide / tetrahydrofuran / -20 °C / |Inert atmosphere 5.2: 0.25 h / -5 °C / |Inert atmosphere 5.3: 0.08 h 6.1: methyl iodide / water; methanol / 0.5 h / 20 °C / |Cooling with ice 6.2: pH 3 - Ca. 7 / |Reflux 7.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C 7.2: pH 2 - 3 View Scheme

1.1: iso-propylmagnesium bromide / tetrahydrofuran / -20 °C / |Inert atmosphere 1.2: 0.25 h / -5 °C / |Inert atmosphere 2.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium bromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C 2.2: pH 2 - 3 View Scheme

hydrogenchloride in ethyl acetate T=20°C; 4 h;