(3R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸合成路线 （共 62 条）
反应条件
1: With 1-methyl-1H-imidazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
T=0 - 20°C; 16 h;
2: With hydrogenchloride in ethanol
T=20°C; 18 h;
3: With sodium hydroxide in ethanol; water
pH=10 - 12; TimeSolvent;
参考文献
FARMA GRS, D.O.O.; ZUPANČIČ, Silvo; ZUPET, Rok
Patent: WO2013/13833 A1, 2013 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 71 percent / HOBT; EDC / dimethylformamide / 16 h / 20 °C
2: 83 percent / HCl / methanol / 1 h / 20 °C
View Scheme
参考文献
SMILAX LABORATORIES LIMITED; MALLELA, Sambhu, Prasad, Sarma; HAVALE, Shrikant, Hanumantappa; BODDEPALLI, Nagabhushana, Rao; GUNJI, Nagarjuna; MOKKAPATI, Bhavani, Sankar
Patent: WO2013/114173 A1, 2013 ;
