反应条件
1.1: n-BuLi / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / -78 °C
2.1: aq. HCl / acetonitrile / 72 h / 20 °C
2.2: 2.41 g / triethylamine / CH2Cl2 / 16 h / 20 °C
3.1: aq. LiOH / tetrahydrofuran / 20 °C
4.1: isobutyl chloroformate; triethylamine / diethyl ether / 0.25 h / -20 °C
4.2: 0.36 g / diethyl ether / 1 h
5.1: 401 mg / aq. silver benzoate / dioxane / 2 h / 20 °C / sonication
6.1: 71 percent / HOBT; EDC / dimethylformamide / 16 h / 20 °C
7.1: 83 percent / HCl / methanol / 1 h / 20 °C
View Scheme
参考文献
Kim, Dooseop; Wang, Liping; Beconi, Maria; Eiermann, George J.; Fisher, Michael H.; He, Huaibing; Hickey, Gerard J.; Kowalchick, Jennifer E.; Leiting, Barbara; Lyons, Kathryn; Marsilio, Frank; McCann, Margaret E.; Patel, Reshma A.; Petrov, Aleksandr; Scapin, Giovanna; Patel, Sangita B.; Roy, Ranabir Sinha; Wu, Joseph K.; Wyvratt, Matthew J.; Zhang, Bei B.; Zhu, Lan; Thornberry, Nancy A.; Weber, Ann E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 141 - 151
