1.1: ethyl acetate / 0.42 h
2.1: hydrogenchloride / dichloromethane; water
2.2: 3 h / Reflux
3.1: sodium hydrogencarbonate / dichloromethane; water / 1 h / 10 - 20 °C
4.1: triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
4.2: 10 h
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; CHANG, Ji-Yeon; LEE, Hyun Seung; KIM, Dong Jun; KO, Myoung-Sil; KIM, Nam Du; CHANG, Young Kil; KIM, Maeng Sup
Patent: WO2011/102640 A2, 2011 ;
1.1: sodium azide / N,N-dimethyl-formamide; water / 2 h / 75 °C
2.1: potassium permanganate / water; acetone / 3 h / -20 - -10 °C
3.1: ethyl acetate / 0.42 h
4.1: hydrogenchloride / dichloromethane; water
4.2: 3 h / Reflux
5.1: sodium hydrogencarbonate / dichloromethane; water / 1 h / 10 - 20 °C
6.1: triphenylphosphine / tetrahydrofuran / 2 h / 50 °C
6.2: 10 h
View Scheme
参考文献
HANMI HOLDINGS CO., LTD.; CHANG, Ji-Yeon; LEE, Hyun Seung; KIM, Dong Jun; KO, Myoung-Sil; KIM, Nam Du; CHANG, Young Kil; KIM, Maeng Sup
Patent: WO2011/102640 A2, 2011 ;