1: With 2,6-dichloro-benzonitrile in methanol
T=25°C;
2: With dimethylsulfide borane complex in tetrahydrofuran
Heating;
3: With pyridinium chlorochromate in dichloromethane
Heating;
参考文献
Campbell, Robert F.; Fitzpatrick, Kevin; Inghardt, Tord; Karlsson, Olle; Nilsson, Kristina; Reilly, John E.; Yet, Larry
Tetrahedron Letters, 2003 , vol. 44, # 29 p. 5477 - 5481
1: meta-mercaptobenzoic acid With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.166667 h;
2: 2-Chloro-isonicotinonitrile in N,N-dimethyl-formamide
T=20°C; 18 h;
3: With hydrogenchloride in water; N,N-dimethyl-formamide
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/57860 A1, 2006 ;
Location in patent: Page/Page column 73 ;
WO 2006/057860 A1
