potassium carbonate in acetone

1: meta-mercaptobenzoic acid With potassium tert-butylate in tetrahydrofuran 0.05 h; 2: 2-methanesulfinylpyrimidine-5-carboxylic acid (4-fluorophenyl)amide in tetrahydrofuran 24 h;

1: meta-mercaptobenzoic acid With sodium hydroxide in 1,4-dioxane; water T=60°C; 2: 1-chloro-1,1-difluoro-methane With sodium hydroxide in 1,4-dioxane; water 9 h; Heating / reflux;

sodium hydroxide

1: 1.) bromine, 2.) potassium carbonate / 1.) dichloromethane, irradiated, 2.75 h, 2.) water, 5-12 deg C, 30 min; 12 deg C, 40 min. 2: sodium borohydride, boron trifluoride etherate / tetrahydrofuran / 5 h / 10 - 15 °C 3: 78.4 percent / sodium hydroxide; HCl / methanol; H2O / 1 h / Heating 4: 92 percent / dry hydrogen bromide / tetrahydrothiophene 1,1-dioxide / 3 h / 15 °C 5: 95.2 percent / dioxane; H2O / 1 h / 70 °C 6: 90 percent / 85percent phosphoric acid / acetic acid / 7 h / Heating 7: 75.1 percent / polyphosphoric acid, water / 1.33 h / 90 °C View Scheme

hydrogenchloride